- Efficient synthesis of some novel symmetrical and unsymmetrical pyridine bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles
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A series of novel bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles bearing pyridine rings was synthesised, by multistep reaction sequences, in good to high yields. Reaction of pyridine-2,5-bis- and pyridine-2,6-bis-carbohydrazides with alkyl- or arylisothio
- Foroughifar, Naser,Mobinikhaledi, Akbar,Rafiee, Abdolhossein
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p. 111 - 114
(2014/03/21)
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- Heterocyclic Amplifiers of Phleomycin. VIII Mono- and Bis-(5'-substituted 1',3',4'-thiadiazol-2'-yl)pyridines and Mono(5'-substituted 1',3',4'-thiadiazol-2'-ylmethyl)pyridines
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A series of mono- and bis-(5'-substituted 1',3',4'-thiadiazol-2'-yl)pyridines with strongly basic side chains, e.g., 3,5-bispyridine (1), and (5'-substituted 1',3',4'-thiadiazol-2'-ylmethyl)pyridines have been prepared for evaluation as amplifiers of phleomycin.Five of this six bis(5'-substituted 1',3',4'-thiadiazol-2'-yl)pyridines were themselves antibacterial under the test conditions, but compounds (1) and the mono (5'-substituted 1',3',4'-thiadiazol-2'-yl)-pyridines and -methylpyridines displayed moderate two-to-three-star activity.
- Barlin, Gordon B.
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p. 1491 - 1497
(2007/10/02)
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