Aqueous metal-free hydrothiolation of enamides and enecarbamates
An efficient and metal-free, anti-Markovnikov selective, hydrothioaltion reaction of enamides and enecarbamates in an aqueous medium is presented. This protocol is operationally simple, mild, and atom-economical. This process provides access to thioethers
The organic photocatalyst (9-mesityl-10-methylacridinum tetrafluoroborate) in the presence of visible light is used to initiate thiol-ene and thiol-yne reactions. Thiyl radicals are generated upon quenching the photoexcited catalyst with a range of thiols
The present invention is directed to a method of alkylating a thiol group (R-S-H) or seleno group (R-Se-H) in a target molecule wherein the method comprises: reacting a target molecule comprising at least one thiol group with a compound of formula (I) or
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(2012/12/13)
A direct method for site-specific protein acetylation
Radicals at work: Radical-mediated thiol-ene addition of the thiol group of Cys to N-vinylacetamide gives acetyl-thialysine (KSAc), a near-perfect mimic of acetyl-lysine (see picture). The reaction is highly efficient with near quantitative con