60202-16-6

Basic information

• Product Name: PROTEIN C
• Synonyms: PROTEIN C SOLUTION;Recombinant Human Activated Protein C;4-[(4-Carboxybutyl)amino]-1-piperidinecarboxylic Acid (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl Ester;7-Ethyl-10-(4-N-aminopentanoic acid)-1-piperidino)carbonyloxycamptothecin;Drotrecogin Alfa;PROTEIN C, ACTIVATED, HUMAN PLASMA;PROTEIN C, HUMAN;PROTEIN C CONTROL PLASMA
• CAS NO: 60202-16-6
• Molecular Formula: C33H38N4O8
• Molecular Weight: 0
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;enzyme
• Mol File: 60202-16-6.mol

Chemical Properties

• Melting Point: 166-168°C
• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• Solubility: H2O: 1 mg/mL
• CAS DataBase Reference: PROTEIN C(CAS DataBase Reference)
• NIST Chemistry Reference: PROTEIN C(60202-16-6)
• EPA Substance Registry System: PROTEIN C(60202-16-6)

Safety Data

• Hazard Codes: B
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 60202-16-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Protein C is used as a therapeutic agent for the treatment of severe sepsis and septic shock. It is administered as drotrecogin alfa (activated), a recombinant form of human activated protein C, which has been shown to reduce mortality in patients with severe sepsis. The drug exerts its effects by inhibiting factors Va and VIIIa, promoting fibrinolysis, and reducing inflammation.
Used in Research and Development:
Protein C is used as a research tool for studying the mechanisms of blood coagulation, fibrinolysis, and inflammation. It helps researchers understand the complex interactions between coagulation factors, inflammatory mediators, and the endothelium, which can lead to the development of novel therapeutic strategies for various diseases.
Used in Diagnostic Applications:
Protein C can be used as a biomarker for assessing the risk of thrombotic events and monitoring the effectiveness of anticoagulant therapies. Low levels of protein C have been associated with an increased risk of venous thromboembolism, and its measurement can help guide treatment decisions in patients with thrombotic disorders.
Used in Drug Delivery Systems:
Protein C can be incorporated into drug delivery systems to enhance its therapeutic effects and improve patient outcomes. For example, protein C can be encapsulated in nanoparticles or liposomes to increase its bioavailability, stability, and targeted delivery to specific tissues or cells.