Enantioselective Palladium(II)-Catalyzed Intramolecular Aminoarylation of Alkenes by Dual N?H and Aryl C?H Bond Cleavage
An asymmetric palladium-catalyzed intramolecular oxidative aminoarylation of alkenes has been developed with quinoline–oxazoline chiral ligands and Ag2CO3 as the oxidant. Various indolines containing a quaternary stereogenic center were synthesized in high yield with excellent enantioselectivity. Preliminary mechanistic studies suggest that the addition of a catalytic amount of phenylglyoxylic acid significantly accelerates the reaction and slightly enhances the enantioselectivity.
Zhang, Wen,Chen, Pinhong,Liu, Guosheng
supporting information
p. 5336 - 5340
(2017/04/27)
Direct Coupling between β-Functionalized Organolithium Compounds and Aryl and Vinyl Halides
Treatment of N-lithio-N-(2-lithioethyl)benzamide with different aromatic and vinylic halides affords directly the corresponding substitution products: functionalized benzamides 3-10.
Barluenga, Jose,Montserrat, Javier M.,Florez, Josefa
p. 6183 - 6186
(2007/10/02)
More Articles about upstream products of 60256-44-2