- Light-induced metal-free transformations of unactivated pyridotriazoles
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A highly efficient and practical method for incorporation of the arylmethylpyridyl moiety into diverse molecules has been developed. This method features the transition metal-free light-induced room temperature transformation of pyridotriazoles into pyridyl carbenes, which are capable of smooth arylation, X-H insertion, and cyclopropanation reactions. The synthetic usefulness of the developed method was illustrated in a facile synthesis of biologically active molecules.
- Zhang, Ziyan,Yadagiri, Dongari,Gevorgyan, Vladimir
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p. 8399 - 8404
(2019/09/30)
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- Synthetic method of 4,4'-(2-pyridylmethylene)diphenol diacetate
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The invention discloses a synthetic method of 4,4'-(2-pyridylmethylene)diphenol diacetate. The preparation method comprises the steps of adding solvent ethyl acetate or dichloroethane alpha-dextrin into raw material phenol, slowly dropwise adding sulfuric acid and 2-pyridylaldehyde while cooling, after the dropwise adding is finished, stopping reaction, adding ethanol for dissolving while cooling,dropwise adding the reactant into a 20% sodium carbonate solution so as to separate out white solids, filtering, washing to obtain an intermediate compound, purifying and drying the intermediate compound, carrying out reflux on the intermediate compound and acetic anhydrideor for 2-4 hours under the effect of anhydrous sodium acetate, and after the reaction is finished, carrying out elutriation,filtration, washing with water, ethanol decolorization and recrystallization, so as to obtain white powder, namely the target compound 4,4'-(2-pyridylmethylene)diphenol diacetate. The preparation method is simple and high in product quality and yield, and the raw materials are easily available.
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Paragraph 0014; 0025; 0028; 0029; 0032; 0033; 0036
(2018/11/22)
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- Synthesis of triphenylmethane derivative: Bisacodyl
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A new method for the synthesis of bisacodyl 1 is described. The key step involves migration of 2-pyridacyl group of phenyl pyridine-2-carboxylate 4 in AlCl3 at 160 °C to yield the intermediate 4-hydroxyphenyl (2-pyridyl) ketone 5a. The reaction of 5a with phenol using H3PO 4 gives 1. This method has advantage over the existing literature methods because easily available pyridine-2-carboxylic acid is used as a starting material instead of the less stable pyridine-2-carboxaldehyde.
- Mereyala, Hari Babu,Sambaru, Kalyani
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p. 615 - 617
(2007/10/03)
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