- Green Synthesis of Fused Imidazo[1,2-a][1,8]naphthyridine Derivatives Catalyzed by DABCO under Solvent-Free Solid-State Conditions and Their Biological Evaluation
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An efficient and eco-friendly methodology has been developed for the construction of fused imidazo[1,2-a][1,8]naphthyridine derivatives in the presence of 1,4-diazabicyclo[2.2.2]octane, and involving various substituted heterocyclic amines with phenacyl b
- Banoth, Sonyanaik,Perugu, Shyam,Boda, Sakram
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p. 709 - 715
(2018/01/22)
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- An Efficient Microwave-Assisted Synthesis of Novel 2-{4-[(3-Aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones and Their Antimicrobial Activity
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The Buchwald–Hartwig amination reaction between 2-chloro-3-aryl-1,8-naphthyridines and 2-(4-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione in the presence of the catalytic system Pd(PPh3)4 and the base KO-t-Bu in toluene was studied. The reaction was initiated by microwave irradiation. Highly efficient synthesis has been developed for 2-{4-[(3-aryl-1,8-naphthyridin-2-yl)amino]phenyl}-1H-benzo[de]isoquinoline-1,3(2H)-diones. Structures of the synthesized compounds were evaluated by IR, 1H and 13C NMR spectroscopy. All products were tested for antimicrobial activity against Escheria coli, Bacillus subtilis, Klebsiella pneumoniae, and Staphylococcus aureus.
- Sakram,Ravi,Ashok,Rambabu,Sonyanaik,Kurumanna
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p. 780 - 788
(2018/06/14)
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- Efficient synthesis of 1,2,4-triazolo[4,3-a][1,8]naphthyridines using nitrous acid under microwave irradiation
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A highly efficient, simple and rapid method for the synthesis of 1,2,4-triazolo[4,3-a][1,8]naphthyridines 8 by the oxidation of the corresponding aryl aldehyde 3-(p-nitrophenyl)-1,8-naphthyridin-2-ylhydrazones 7 using nitrous acid (NaNO2/CHsub
- Mogilaiah,Prashanthi,Vidya
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p. 2641 - 2645
(2007/10/03)
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