604790-72-9

A pyrone compound represented by formula (1) has an excellent controlling effect on pests. Since the compound of formula (1) has a controlling activity on pests, the compound is useful as an active ingredient of a pest control agent.

The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells: wherein W, Cyc, p, Y, X, Z, R, R1, R2, R3, R4, I, m and n are as defined for Formula (I) h

The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia wherein W is C1-C6 alkyl, halogen, or argyl; Cyc is C3 or C4 cycloalkyl; p is 0-3 for Cyc being C4 cycloalkyl and p=0-2 for Cyc being C3 cycloalkyl; Y is O, S, or NR, where R═H, alkyl or aryl; X is O, S, NR, or CR3R4; Z is H, alkyl, cycloalkyl, aryl or (cyclo)alkylcarbonyl; R1 is H, alkyl, aryl or O; R2 is H, alkyl or aryl; R3 and R4 are, independently, H, alkyl or aryl; and n is an integer from 1 to 10; or a pharmaceutically acceptable salt, ester or prodrug thereof.