- New Pyrano-4H-benzo[g]chromene-5,10-diones with Antiparasitic and Antioxidant Activities
-
New pyranonaphthoquinone derivatives were synthesized and investigated for their activity against Trypanosoma brucei, Leishmania major, and Toxoplasma gondii parasites. The pentafluorophenyl derivative was efficacious against T. brucei with single digit m
- Al Nasr, Ibrahim S.,Jentzsch, Jana,Shaikh, Amin,Singh Shuveksh, Priti,Koko, Waleed S.,Khan, Tariq A.,Ahmed, Khursheed,Schobert, Rainer,Ersfeld, Klaus,Biersack, Bernhard
-
-
- Manganese-organic framework assembled by 5-((4′-(tetrazol-5″-yl)benzyl)oxy)isophthalic acid: A solvent-free catalyst for the formation of carbon–carbon bond
-
A new three-dimensional manganese-based metal–organic framework Mn4L2(HL)(H2O)5, (1), based on semi-rigid 5-((4′-(tetrazol-5′’-yl)benzyl)oxy)isophthalic acid ligand (H3L) have been prepared and charac
- Jiang, Yansong,Xu, Jianing,Zhu, Ziqian,Jiang, Changwei,Ma, Lin,Wang, Hui,Wang, Li,Fan, Yong
-
-
- A luminescent inorganic-organic hybrid, [Cd(C16H10N2O8S)(H2O)], for the selective and recyclable detection of chromates and dichromates in aqueous solution
-
A new inorganic-organic hybrid compound [Cd(H2L)(H2O)], 1, {where, H2L2- = 4,4′-sulfonylbis(phenylene)bis(oxamate)} has been prepared under solvothermal conditions. The compound has a three-dimensional structure
- Kundu, Tanaya,Manna, Krishna,Jana, Ajay K.,Natarajan, Srinivasan
-
p. 13263 - 13270
(2019/08/30)
-
- Amino Acid Amide based Ionic Liquid as an Efficient Organo-Catalyst for Solvent-free Knoevenagel Condensation at Room Temperature
-
Abstract: Ionic liquids of amino acid amide were synthesized and used as an efficient catalyst for solvent-free Knoevenagel condensation. Synthesized ionic liquids are an environmentally benign, inexpensive, metal free and plays the dual role of solvent as well as an efficient catalyst for Knoevenagel condensation. A wide range of aliphatic, aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. Additionally, the catalyst is easily separable and recyclable without loss of activity. Graphic Abstract: [Figure not available: see fulltext.].
- Burate, Pralhad A.,Javle, Balasaheb R.,Desale, Pranjal H.,Kinage, Anil K.
-
p. 2368 - 2375
(2019/06/17)
-
- FIBROTIC TREATMENT
-
The present invention relates to a method for the treatment of fibrosis, in particular cardiac fibrosis, comprising the administration of an inhibitor of insulin-regulated aminopeptidase (IRAP). Preferable the IRAP inhibitor is chosen from the group inclu
- -
-
Page/Page column 81
(2017/02/24)
-
- Electrochemical approach for synthesis of 3-substituted indole derivatives
-
An efficient and economical method was developed for synthesis of 3-substituted indole by using electrochemically induced condensation of various aldehyde, indole and malononitrile.
- Singh, Vinay K.,Dubey, Rahul,Upadhyay, Abhishek,Sharma, Laxmi Kant,Singh, Rana Krishna Pal
-
supporting information
p. 4227 - 4231
(2017/10/12)
-
- 4H-PYRAN COMPOUNDS AS INSULIN-REGULATED AMINOPEPTIDASE (IRAP) INHIBITORS
-
The present disclosure relates to 4H-pyran compounds of formula (I) and their use in therapy, to compositions and agents comprising said compounds, to methods of treatment using said compounds, and their use in the manufacture of medicaments. The disclosu
- -
-
Page/Page column 49
(2016/12/01)
-
- An Efficient One-pot Three-component Process for Synthesis of Perfluoroalkylated Quinolizines
-
A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. Moderate yields were obtained under mil
- Shen, Dandan,Xu, Yanjie,He, Dong,Han, Jing,Chen, Jie,Deng, Hongmei,Shao, Min,Zhang, Hui,Cao, Weiguo
-
p. 524 - 532
(2016/06/01)
-
- Fluorous bispidine: A bifunctional reagent for copper-catalyzed oxidation and knoevenagel condensation reactions in water
-
Fluorous bispidine-type ligands have been developed to facilitate its recovery and reusability and to demonstrate its bifunctional property as a ligand and base in copper-catalyzed aerobic oxidation, the Knoevenagel condensation and tandem oxidation/Knoevenagel condensation in water under mild conditions. Application of the fluorous ligand was also extended to the surfactant-free copper-catalyzed allylic and benzylic sp3 C-H oxidation reaction in water. The fluorous ligands could be recovered using F-SPE with recovery ranging from 91-97% and could be reused five times with little loss of activity.
- Ang, Wei Jie,Chng, Yong Sheng,Lam, Yulin
-
p. 81415 - 81428
(2015/10/06)
-
- One-pot synthesis of polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety
-
Polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety were readily prepared in high yields via one-pot multicomponent reaction catalyzed by piperidine. This present protocol provides an efficient synthetic route to the target compoun
- Ye, Zhenjun,Xu, Renbo,Shao, Xusheng,Xu, Xiaoyong,Li, Zhong
-
experimental part
p. 4991 - 4994
(2011/02/21)
-
- Design, multicomponent synthesis, and bioactivities of novel neonicotinoid analogues with 1,4-dihydropyridine scaffold
-
Novel neonicotinoid analogues bearing a 1,4-dihydropridine scaffold were designed and synthesized by multicomponent reactions (MCRs) to enhance π-π stacking. The synthesized compounds were identified by 1H NMR, 13C NMR, high-resoluti
- Zhang, Wenwen,Yang, Xiaobao,Chen, Weidong,Xu, Xiaoyong,Li, Lu,Zhai, Hongbin,Li, Zhong
-
experimental part
p. 2741 - 2745
(2011/07/31)
-
- Designing tetrahydroimidazo[1,2- a ]pyridine derivatives via catalyst-free Aza-Diels-Alder Reaction (ADAR) and their insecticidal evaluation
-
A series of tetrahydroimidazo[1,2-a]pyridine derivatives were synthesized by the reaction of 2-vinyl-4,5-dihydroimidazole derivatives with substituted benzylidenemalononitrile via a catalyst-free aza-Diels-Alder reaction. Insecticidal activities of target
- Zhang, Wenwen,Chen, Yinbo,Chen, Weidong,Liu, Zewen,Li, Zhong
-
scheme or table
p. 6296 - 6299
(2011/08/05)
-
- Benzoxazinoes/benzothiazinones as serine protease inhibitors
-
This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnornal thrombosis.
- -
-
-
- Quinoxalinones as serine protease inhibitors such as factor XA and thrombin
-
This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
- -
-
-
- CATALYSIS OF THE KNOEVENAGEL CONDENSATION.
-
Xonotlite alone or made more basic by doping of potassium t-butoxide catalyses the title reaction between aromatic aldehydes and malononitrile or alkyl cyanoacetates.At ambient temperatures, this procedure specifically gives high yields of E olefinic Knoe
- Chalais, Stephane,Laszlo, Pierre,Mathy, Arthur
-
p. 4453 - 4454
(2007/10/02)
-