- Selective Oxidation of Alkylarenes to the Aromatic Ketones or Benzaldehydes with Water
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Here a palladium-catalyzed oxidation method for converting alkylarenes into the aromatic ketones or benzaldehydes with water as the only oxygen donor is reported. This C-H bond oxidation functionalization does not require other oxidants and hydrogen accep
- Du, Jihong,Duan, Baogen,Liu, Kun,Liu, Renhua,Yu, Feifei,Yuan, Yongkun,Zhang, Chenyang,Zhang, Jin
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supporting information
(2022/02/09)
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- 4,4′-Benzophenone-O,O′-disulfamate: A potent inhibitor of steroid sulfatase
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We investigated whether the benzophenone moiety can be used as core element of steroid sulfatase (STS) inhibitors. While 4- and 3-benzophenone-O-sulfamates inhibit STS with IC50 values between 5 and 7 μM irrespective of additional hydroxy and m
- Nussbaumer, Peter,Bilban, Melitta,Billich, Andreas
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p. 2093 - 2095
(2007/10/03)
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- Cycloadditions of substituted benzopyran-4-ones to electron-rich dienes: a new route to xanthone derivatives
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The benzopyranones 1 and 3 reacted with 2,3-dimethyl-1,3-butadiene in the presence of titanium (IV) chloride to give the corresponding (4 + 2) cycloadducts 8 and 11, the former undergoing facile deformylation to give 9 and 10. Compounds 1, 3, and 4 underwent efficient uncatalysed cycloaddition to 1- methoxy-3-(trimethylsilyloxy)-l,3-butadiene 12 to give the respective adducts 13,14, and 18 as mixtures of C-l stereoisomers. Heating the 3-arylsulphinylchromone 5 with the diene 12 afforded 3-hydroxyxanthone 23 in 50% yield, the presumed cycloaddition - elimination sequence constituting a new route to xanthone systems. Desilylation of 13,14, and 18 in acidic media provided 25,26, and 27 respectively.
- Cremins, Peter J.,Saengchantara, Suthiweth T.,Wallace, Timothy W.
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p. 3075 - 3082
(2007/10/02)
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- Production of hydroxy arylophenones
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Production of a hydroxy arylophenone by reacting an aromatic carboxylic acid Ar(--CO2 H)p where Ar is an aromatic radical, (--CO2 H) is an aromatic carboxylic acid group, and p is 1 or 2 with an aromatic compound H--Ar'--OH where Ar' is an aromatic radical and --H and --OH are aromatically bound para to each other in a benzenoid ring, in the presence of an alkyl sulphonic acid, particularly methane sulphonic acid, to produce a hydroxy arylophenone of formula Ar(--CO--Ar'--OH)p where the carbonyl and hydroxyl groups are para to each other in the hydroxyl-containing benzenoid ring of Ar'. The production of the hydroxy arylophenone proceeds through the intermediate ester (H--Ar'--O--CO--)p Ar and the production of the hydroxy arylophenone starting from the ester is also claimed.
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