- Synthesis and preliminary pharmacological evaluation of aryl dithiolethiones with cyclooxygenase-2-selective inhibitory activity and hydrogen sulfide-releasing properties
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A series of 5-aryl-1,2-dithiolethiones and 5-aryl-1,2-dithiole-3-ones were investigated as hydrogen sulfide-releasing anti-inflammatory drugs. Generally, phenolic acetophenones were best protected by methoxymethyl groups and the dithiolethione group insta
- Zanatta, Shannon D.,Jarrott, Bevyn,Williams, Spencer J.
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scheme or table
p. 946 - 957
(2011/08/05)
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- 1,3-Diphenylprop-2-En-1-One Derivative Compounds, Preparation Method Thereof and Uses of Same
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The invention relates to substituted 1,3-diphenylprop-2-en-1-one derivative compounds, pharmaceutical and/or cosmetic compositions containing same, and the applications thereof in therapeutics and cosmetics. The invention also relates to a method for prep
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Page/Page column 21
(2008/06/13)
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- DITHIOLE COMPOUNDS AS COX INHIBITORS
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A compound of formula (I) wherein: R1 and R2 are the same or different and are independently selected from H and a shielding group; X and Y are each independently selected from N and CH; R3 is hydroxy, alkoxy, acyloxy or a
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Page/Page column 38
(2008/12/05)
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- Friedel-Crafts ipso-Acylations of 2-Substituted 4-tert-Butylanisoles and p-tert-Butylmethoxymetacyclophanes
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Acylation of 1,n-bis(5-tert-butyl-2-methoxyphenyl)alkanes 6 with acid chloride or acid anhydride in the presence of Lewis acids afforded only the product arizing from two-fold ipso-acylation at the tert-butyl groups; similar reaction of 1,2-bis(5-tert-butyl-2-methoxy-3-methylphenyl)alkanes 8 led only to the recovery of the starting compounds, thus differing from the nitration of 8 with fuming HNO3 at room temperature which affords in quantitative yield the selective ipso-nitration product at the tert-butyl groups.However, the ipso-acylation reactions of 5,13-di-tert-butyl-8,16-dimethoxymeta-cyclophane 15 led to the first-reported direct introduction of an acyl group due to a through-space electronic interaction with the opposing benzene ring.In contrast the selective ipso-acylation reaction was not observed in the case of the larger ring sized macrocyclic meta-cyclophane, p-tert-butyltetramethoxycalix(4)arene.
- Yamato, Takehiko,Maeda, Kenji,Kamimura, Hideo,Noda, Kozo,Tashiro, Masashi
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p. 1865 - 1889
(2007/10/03)
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- SIGMATROPIC REARRANGEMENT OF ARYLHYDRAZONES FOLLOWED BY 1,2-SHIFT OF AN ARYL GROUP. VII
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Arylhydrazones of ethyl 4-methoxy-3,5-dimethylphenylglyoxylate and 4-methoxy-3,5-dimethylacetophenone rearrange in hot polyphosphoric acid to give biphenyl derivatives arising from a sigmatropic rearrangement followed by an aryl group 1,2-shift.Stru
- Sannicolo, Franco
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