Bidentate hydroxyalkyl NHC ligands for the copper-catalyzed asymmetric allylic substitution of allyl phosphates with grignard reagents
Demonstrating their potential: Bidentate alkoxy NHC ligands have been used in the copper-catalyzed asymmetric allylic alkylation of allyl phosphates with Grignard reagents (see scheme). The method provides access to tertiary and quaternary chiral centers with high regio- and enantioselectivity. The system is also applied to the synthesis of chiral E,E-dienes, a key structural motif prevalent in natural products. Copyright
Magrez, Magaly,Le Guen, Yann,Basle, Olivier,Crevisy, Christophe,Mauduit, Marc
supporting information
p. 1199 - 1203
(2013/02/25)
One-Pot and Regioselective Synthesis of Alkenes and Deuterioalkenes from α-Chloro Carboxylic Acid Chlorides via a Tandem Addition of Two Different Nucleophiles (Grignard Reagents, Hydride or Deuteride) and Further Lithiation
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Barluenga, Jose,Yus, Miguel,Concellon, Jose M.,Bernad, Pablo
p. 609 - 611
(2007/10/02)
Synthesis of Olefins from α-Chlorocarbonyl Compounds
Olefins or diolefins with the double bonds in predetermined positions are obtained in moderate to good yields by treatment of α-chlorocarbonyl compounds with Grignard reagents and lithium in a single process.
Barluenga, Jose,Yus, Miguel,Concellon, Jose M.,Bernad, Pablo
p. 677 - 692
(2007/10/02)
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