- One-pot ring-closing metathesis-alkene cross metathesis reactions of sulfamide-linked enynes
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Ring-closing metathesis (RCM) of sulfamide-linked enynes 7, 11 and 12 containing disubstituted alkynes afforded a series of novel 7-membered cyclic sulfamides 13-15 in good yield. Substrates 5, 9 and 10 containing mono-substituted alkynes gave either simple RCM products 18a-c or those arising from combinations of enyne RCM and olefin cross metathesis 16/17a-c depending on the reaction conditions. Notably, in the presence of two equivalents of styrene or ethyl acrylate, substrates 5, 9 and 10 containing terminal alkynes underwent selective enyne-RCM-olefin-cross metathesis to provide cyclic sulfamides 17a-c and 19b,c in yields of 54-83%. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
- Salim, Sofia S.,Bellingham, Richard K.,Brown, Richard C. D.
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- Synthesis of Heterocyclic and Carbocyclic Fluoro-olefins by Ring-Closing Metathesis
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(Equation presented) Ring-closing metathesis (RCM) of vinyl fluoride-containing dienes in the presence of ruthenium alkylidene carbene complex 11 proceeded efficiently to give six- and seven-membered cyclic vinyl fluorides. The RCM reaction was used to pr
- Salim, Sofia S.,Bellingham, Richard K.,Satcharoen, Vachiraporn,Brown, Richard C. D.
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p. 3403 - 3406
(2007/10/03)
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