- Novel long alkyl side chain benzo[a]phenoxazinium chlorides: synthesis, photophysical behaviour and DNA interaction
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Several fluorescent benzo[a]phenoxazinium chlorides possessing a propyl-, octyl-, decyl-, dodecyl- or tetradecylamino at the 5-position of the heterocyclic moiety were efficiently synthesised. The absorption and emission maxima of all compounds lie in the
- Alves, Carla M.A.,Naik, Sarala,Coutinho, Paulo J.G.,Gon?alves, M. Sameiro T.
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- Synthesis of new benzo[a]phenoxazinium probes possessing carboxylic ester, hydroxyl and amino functional groups: Photophysical studies in dry ethanol and conjugation with CdTe quantum dots
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A new series of benzo[a]phenoxazinium chlorides possessing hydroxyl, ethyl ester and amino functional groups as terminal substituents at the 9- and 5-positions of the tetracyclic aromatic system in different combinations, was synthesized. A photophysical
- Raju, B. Rama,Garcia, Arlindo M. Fontes,Costa, A. Luísa S.,Coutinho, Paulo J.G.,Gon?alves, M. Sameiro T.
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- BENZOPHENOXAZINE DERIVATIVES FOR DIAGNOSIS OF NEOPLASIA OR INFECTION
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The present disclosure is related to the synthesis and applications of a benzo[a]phenoxazine. It displays good photophysical properties, such as high molar extinction coefficient, good fluorescence quantum yield and solubility in water. The present invent
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Paragraph 0063
(2019/10/29)
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- Synthesis and photophysical properties of side-chain chlorinated benzo[a]phenoxazinium chlorides
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Novel water-soluble benzo[a]phenoxazinium chlorides mono- or disubstituted with 3-chloropropyl groups at the amine of position 9, and also at the hydroxyl function at position 2, were synthesized. These compounds possessing one, two or three chlorinated t
- Raju, B. Rama,Firmino, A. Daniela G.,Costa, A. Luísa S.,Coutinho, Paulo J.G.,Gon?alves, M. Sameiro T.
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p. 2451 - 2461
(2013/03/14)
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- N-(di)icosyl-substituted benzo[a]phenoxazinium chlorides: Synthesis and evaluation as near-infrared membrane probes
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Five benzo[a]phenoxazinium chlorides containing alkyl chains with twenty carbon atoms at the 5- or 9-positions of the tetracyclic ring were efficiently synthesised and characterised by UV/Vis and NIR spectroscopy. The absorption and emission maxima in ethanol occur in the range 627-641 nm and 645-676 nm, respectively, with quantum yields varying from 0.14 to 0.38. Preliminary photophysical studies with these fluorochromophores in zwitterionic [2,3-bis(palmitoyloxy)propyl-2-(trimethylammonio)ethyl phosphate, DPPC] and cationic (N,N-dimethyl-N-octadecyloctadecan-1-aminium bromide, DODAB) vesicles were carried out. The results showed that the new benzo[a]phenoxazinium derivatives are able to detect the gel to liquid-crystalline lipid phase transition through variations in either the extent of H-aggregation or in the acid-base equilibrium. Novel benzo[a]phenoxazinium chlorides possessing icosyl groups as substituents at the 5- or 9-positions of the tetracyclic ring were photophysically studied in both zwitterionic and cationic vesicles. The results revealed that these fluorochromophores are able to detect the gel to liquid-crystalline lipid phase transition through variations either in the extent of H-aggregation or in an acid-base equilibrium. Copyright
- Naik, Sarala,Alves, Carla M. A.,Coutinho, Paulo J. G.,Goncalves, M. Sameiro T.
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p. 2491 - 2497
(2011/06/10)
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- Efficient copper-catalyzed N-arylations of nitrogen-containing heterocycles and aliphatic amines in water
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A simple and efficient copper-catalyzed method has been developed for N-arylations of nitrogen-containing heterocycles and aliphatic amines in water. The protocol uses (1E,2E)-oxalaldehyde dioxime (OADO) as the ligand, and water as the solvent, and shows good tolerance towards various functional groups.
- Li, Xufeng,Yang, Daoshan,Jiang, Yuyang,Fu, Hua
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experimental part
p. 1097 - 1105
(2010/08/06)
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- New long alkyl side-chain benzo[a]phenoxazines as micellisation probes
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Several novel fluorescent benzo[a]phenoxazinium chlorides possessing a long aliphatic chain substituent at the 5-amino function of the heterocycle were efficiently synthesised. All compounds obtained absorbed and emitted at longer wavelengths with moderat
- Alves, Carla M.A.,Naik, Sarala,Coutinho, Paulo J.G.,Gon?alves, M. Sameiro T.
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experimental part
p. 4470 - 4474
(2009/12/03)
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- Synthesis of Pyrrolidines and Pyrrolidinones by the Rhodium Complex Catalyzed Cyclization of Unsaturated Amines
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N-Allylic arylamines react with carbon monoxide, sodium borohydride, 2-propanol, and catalytic amounts of the zwitterionic complex η6-C6H6BPh3-Rh(COD)+ (1), to form pyrrolidines as the main products in most cases.Pyrrolidinones result from N-allylic alkylamines.An alternate route to the lactams from N-allylic alkylamines involves synthesis gas instead of CO/NaBH4, together with the dual catalytic system 1/2.Complementary to the N-allylic arylamine route to pyrrolidines with NaBH4 and 1 is the use of synthesis gas, 1, and 1,4-bis(diphenylphosphino)butane.
- Zhou, Jian-Qiang,Alper, Howard
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p. 3328 - 3331
(2007/10/02)
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