- Preparation method of nitrile compound
-
The present invention belongs to the field of organic synthesis technology, specifically relates to a method for preparing a nitrile compound, aldehyde oxime derivatives as raw materials, adding DPPA and DBU, reacting in an organic solvent, one step to pr
- -
-
Paragraph 0048-0050
(2022/01/08)
-
- Discovery and characterization of a novel perylenephotoreductant for the activation of aryl halides
-
To develop a photocatalyst with catalytical activity for substrates with low reactivities is always highly desired. Herein, based on the principle of structure–property relationships, we rationally designed the natural product cercosporin, the naturally occurring perylenequinonoid pigment, to develop a novel organic perylenephotoreductant, hexacetyl reduced cercosporin (HARCP), through structural manipulation. Compared with cercosporin, HARCP shows prominent electrochemical and photophysical characteristics with greatly improved photoreductive activity, fluorescence lifetime and fluorescence quantum yield. These properties allowed HARCP as a powerful photoreductant to efficiently realize a series of benchmark reactions, including photoreduction, alkoxylation and hydroxylation to construct C–H and C–O bonds using aryl halides as substrates under mild conditions, all of which have never been achieved by the same photocatalyst. Thus, this study well supports the notion that the principle between structural manipulation and photocatalytic activity is of great significance to design customized photocatalysts for photoredox chemistry.
- Guo, Baodang,Huang, Shuping,Li, Jia,Li, Min,Liu, Xuanzhong,Rao, Yijian,Wu, Yawen,Yin, Huimin,Yuan, Zhenbo,Zhang, Yan
-
p. 111 - 120
(2021/06/16)
-
- Visible-Light Promoted C–O Bond Formation with an Integrated Carbon Nitride–Nickel Heterogeneous Photocatalyst
-
Ni-deposited mesoporous graphitic carbon nitride (Ni-mpg-CNx) is introduced as an inexpensive, robust, easily synthesizable and recyclable material that functions as an integrated dual photocatalytic system. This material overcomes the need of expensive photosensitizers, organic ligands and additives as well as limitations of catalyst deactivation in the existing photo/Ni dual catalytic cross-coupling reactions. The dual catalytic Ni-mpg-CNx is demonstrated for C–O coupling between aryl halides and aliphatic alcohols under mild condition. The reaction affords the ether product in good-to-excellent yields (60–92 %) with broad substrate scope, including heteroaryl and aryl halides bearing electron-withdrawing, -donating and neutral groups. The heterogeneous Ni-mpg-CNx can be easily recovered from the reaction mixture and reused over multiple cycles without loss of activity. The findings highlight exciting opportunities for dual catalysis promoted by a fully heterogeneous system.
- Vijeta, Arjun,Casadevall, Carla,Roy, Souvik,Reisner, Erwin
-
supporting information
p. 8494 - 8499
(2021/03/08)
-
- COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES
-
The present disclosure relates to compounds according to Formula (I), useful for treating diseases.
- -
-
Paragraph 00675-00676
(2019/03/12)
-
- Cobalt-containing mesoporous ZSM-5 zeolite catalyzed C=C bond cleavage of alkenes to form nitriles
-
Cobalt-containing mesoporous ZSM-5 zeolite (Co-ZSM-5-M) catalyst showed high catalytic activity, selectivity, and excellent reusability in C=C double-bond cleavage of alkenes to form aromatic nitriles. All reactions proceeded smoothly to afford the desired target products in moderate to high yields under the optimal conditions. The Co-ZSM-5-M catalyst was recycled up to at least seven consecutive cycles without significant loss of its catalytic performance.
- Xu, Shuling,Cai, Tianhao,Yun, Zhi
-
p. 221 - 224
(2016/01/20)
-
- Cyanocalix[4]arenes: Synthesis, crystal structures and reactivity studies
-
Herein, we describe an improved method to synthesise mono-, di- and tetra-cyanocalix[4]arene and report their crystal structure determinations. We also report our attempts to further functionalise the cyanocalix[4]arenes into dithiadiazolyl-calix[4]arenes
- Applewhite, Malcolm J.,Haynes, Delia A.,Arnott, Gareth E.
-
p. 475 - 484
(2016/04/19)
-
- Carnosine analogues containing NO-donor substructures: Synthesis, physico-chemical characterization and preliminary pharmacological profile
-
The synthesis, physico-chemical, and biological characterisation of a short series of carnosine amides bearing NO-donor nitrooxy functionalities are described. The NO-donor carnosine analogues and their des-NO derivatives display carnosine-like properties
- Bertinaria, Massimo,Rolando, Barbara,Giorgis, Marta,Montanaro, Gabriele,Marini, Elisabetta,Collino, Massimo,Benetti, Elisa,Daniele, Pier Giuseppe,Fruttero, Roberta,Gasco, Alberto
-
experimental part
p. 103 - 112
(2012/08/29)
-
- Pd/C(en) catalyzed chemoselective hydrogenation in the presence of aryl nitriles
-
Aromatic nitriles are not only important components of natural products, pharmaceuticals, herbicides and agrochemicals but also a synthetic equivalent of various functionalities. The development of synthetic methods of aromatic nitriles have been increasing in terms of its usefulness. Since aromatic nitriles are susceptible to the hydrogenation, it has been desired for the development of chemoselective hydrogenation method with retention of nitrile groups. Pd/C is one of the most popular catalysts for hydrogenation and many of reducible functional groups such as multiple bonds, benzyl ethers, N-Cbzs, nitro groups and so on could be easily reduced under the conditions. Therefore, it is very difficult to achieve the chemoselective hydrogenation of substrates containing two or more reducible functional groups. We have found that a Pd/C catalyst formed an isolable complex with ethylenediamine (en) employed as catalytic poison, and the complex [Pd/C(en)] catalyzed chemoselective hydrogenation of a variety of reducible functionalities distinguishing O-benzyl, N-Cbz and O-TBDMS protective groups, benzyl alcohols and epoxides. In the course of these investigations, we found the aryl nitriles could survive under the Pd/C(en)-catalyzed hydrogenation conditions in THF whose choice is important for the effective suppression. This methodology could be applied to the selective hydrogenation of alkene and alkyne functionalities in the presence of aromatic nitrile.
- Maegawa, Tomohiro,Fujita, Yuki,Sakurai, Ai,Akashi, Akira,Sato, Mutsumi,Oono, Keiji,Sajiki, Hironao
-
p. 837 - 839
(2008/02/07)
-
- Thermodynamics and kinetics of homolytic cleavage of carbon-oxygen bonds in radical anions obtained by electrochemical reduction of alkyl aryl ethers
-
The properties and the reactivity of the radical anions of 4-cyanophenyl alkyl ethers and naphthyl alkyl ethers have been determined by electrochemical methods. Under electrochemical conditions homolytic dissociation is the only observed process. Cyclic voltammetry studies lead to the conclusion that this process is a stepwise one, the initially produced radical anion cleaving by a slow first order reaction followed by a second electron transfer in a DISP1 mechanism. A Marcus type relationship between the cleavage rate constants and the standard free energy of the reaction leads to an intrinsic barrier in the range of 0.7 to 0.8 eV. The analysis of the intrinsic barrier values indicates that solvent organisation represents a modest contribution, the bond dissociation energy of the radical anion (structural contribution I being the main factor in the total barrier. Previously unknown bond dissociation energies of naphthyl ethers have been estimated using the correlations established in this work.
- Andrieux, Claude P.,Farriol, Maria,Gallardo, Iluminada,Marquet, Jordi
-
p. 985 - 990
(2007/10/03)
-
- Synthesis of N1-substituted benzamidines. Effects on blood coagulation, platelet aggregation and antiarrhythmic activity.
-
A series of N1-substituted-4-alkoxybenzamidines was synthesized and tested in vitro for their inhibitory effects on blood coagulation and agonist induced platelet aggregation. The antiarrhythmic activity against chloroform-induced arrhythmias in mice was also evaluated. The biological activity of the title compounds is reported in comparison with that of procainamide; among the new products described, IVi and IVe were found to have the most potent anti-platelet and antiarrhythmic activity, respectively. The structure-activity relationships are discussed.
- Ferroni,Simoni,Manfredini,Guarneri,Orlandini,Barbieri,Franze,Mugelli
-
p. 665 - 669
(2007/10/02)
-
- 1,2,4-OXADIAZOLE DERIVATIVES HAVING MONOAMINE OXIDASE B ENZYME-INHIBITORY ACTIVITY
-
A 1,2,4-oxadiazole derivative is represented by the following general formula (I): wherein R1 represents a lower alkyl or cycloalkyl group, a lower alkyl group substituted with a halogen atom, a lower alkylamino group or a phenyl group; R2 represents a hy
- -
-
-
- Development of a Series of Phenyltetrazole Leukotriene D4(LTD4) Receptor Antagonist
-
A hypothetical model for receptor binding of leukotriene D4 (LTD4) was deduced from conformational analysis of LTD4 and from the structure-activity relationships (SAR) of known LTD4 receptor antagonists.A new structural series of LTD4 receptor antagonists exemplified by 5--2--2H-tetrazole was designed in which a phenyltetrazole moiety was incorporated as a receptor binding equivalent of the triene unit of LTD4.A number of these phenyltetrazoles were prepared and found to possess LTD4 receptor antagonist activity.The structure-activity relationship (SAR) of this series is described.
- Harper, Richard W.,Herron, David K.,Bollinger, Nancy G.,Sawyer, J. Scott,Baldwin, Ronald F.,et al.
-
p. 1191 - 1200
(2007/10/02)
-
- Anti-arythmiques apparentes au procainamide II. Synthese et etude pharmacologique
-
Anti-arrhythmic agents related to procainamide II.Synthesis and pharmacological study.In view of their marked anti-arrhythmic activity, we continued our studies on the N--4-alkoxy-benzamidines described previously.We prepared p
- Reynaud, Pierre,Brion, Jean-Daniel,Nguyen-Tri-Xuong, Emmanuel,Davrinche, Catherine,Pieri, Francois,Arnold-Guerin, Marie-Luce
-
p. 427 - 434
(2007/10/02)
-