- 6-(acetyl-AA-sulfydryl)purine, and synthesis, activity and application thereof
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The invention discloses 6-(acetyl-AA-sulfydryl)purine (wherein AA in the formula is Asp, Met and Ser residues) as shown in the specification, and a preparation method and antitumor activity thereof. The invention discloses application of 6-(acetyl-AA-sulf
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Paragraph 0015; 0016
(2020/12/10)
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- Synthesis and biological evaluation of some 6-substituted purines
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We report herein the synthesis and the in vitro antileishmanial evaluation of a series of 6-substituted purines. The most active compounds against Leishmania amazonensis promastigotes were 6-(3′-chloropropylthio)purine 2 (D.A. Benson, I. Karsch-Mizrachi, D.J. Lipman, J. Ostell, B.A. Rapp, D.L. Wheeler, Genbank. Nucleic Acids Res. 28 (2000) 15-18; E.V. Aleksandrova, P.M.I.E. Valashek, J. Med. Pharm. Chem. 35 (2001) 172-173), 6-(3′-(thioethylamine)propylthio)purine 5, 6-(α-aceticacidthio)purine 7 and 6-(6′-deoxy-1′-O-methyl-β-d-ribofuranose)purine 14 with an IC50 = 50, 50, 39 and 29 μM, respectively.
- Braga, Fernanda Gambogi,Coimbra, Elaine Soares,de Oliveira Matos, Magnum,Lino Carmo, Arturene Maria,Cancio, Marisa Damato,da Silva, Adilson David
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p. 530 - 537
(2008/02/10)
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- Synthesis of heterylthioalkanoic acids and their use for concentration of tungsten-containing ores
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Methods for preparing a series of heterylthioalkanoic acids inclulding α-(indol-3-ylthio)propionic, α-(indol-3-ylthio)butyric, and pur-6-ylthioacetic acids were developed, and flotation properties of these compounds in concentration of tungsten-containing ores are studied.
- Levkovskaya,Mirskova,Bel'kova
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p. 1849 - 1852
(2007/10/03)
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