- Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication
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We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase peptide synthesis (SPPS). Our study culminated with the development of an ultrasound-assisted strategy (US-SPPS) that allowed for the synthesis of different biologically active peptides (up to 44-mer), with a remarkable savings of material and reaction time. Noteworthy, ultrasonic irradiation did not exacerbate the main side reactions and improved the synthesis of peptides endowed with "difficult sequences", placing the US-SPPS among the current high-efficient peptide synthetic strategies.
- Merlino, Francesco,Tomassi, Stefano,Yousif, Ali M.,Messere, Anna,Marinelli, Luciana,Grieco, Paolo,Novellino, Ettore,Cosconati, Sandro,Di Maro, Salvatore
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supporting information
p. 6378 - 6382
(2019/09/06)
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- Nicotinoyl peptide derivatives and cosmetic composition comprising the same
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The present invention relates to nicotinoyl peptide derivatives, wherein neuropeptides are connected to nicotinic acid, and a cosmetic composition comprising the same. The peptide derivatives according to the present invention have good collagen generation and anti-inflammatory activities to show an excellent anti-wrinkle effect, little cytotoxicity, water-solubility, and good stability during long-term storage. Therefore, they can be effectively used for preparing an anti-aging cosmetic composition.
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