60904-49-6

Basic information

• Product Name: 2-(4-methoxyphenoxy)-1-(4-methylphenyl)ethanone
• Synonyms: 2-(4-methoxyphenoxy)-1-(4-methylphenyl)ethanone
• CAS NO: 60904-49-6
• Molecular Formula: C₁₆H₁₆O₃
• Molecular Weight: 256.29644
• Mol File: 60904-49-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-methoxyphenoxy)-1-(4-methylphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenoxy)-1-(4-methylphenyl)ethanone(60904-49-6)
• EPA Substance Registry System: 2-(4-methoxyphenoxy)-1-(4-methylphenyl)ethanone(60904-49-6)

Safety Data

• Hazardous Substances Data: 60904-49-6(Hazardous Substances Data)

Upstream product

• 150-76-5 4-methoxy-phenol 
• 619-41-0 4-(bromoacetyl)toluene 

Downstream Products

• 1189144-70-4 5-methoxy-3-(p-tolyl)benzofuran 
• 152862-80-1 2-(4-Bromomethyl-phenyl)-5-methoxy-benzofuran 
• 22772-24-3 2-(4'-methylphenyl)-5-methoxybenzo[b]furan 

Relevant articles and documents

Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)participates in diverse cancer-associated signaling pathways, playing an oncogenic role in multiple human cancers, including hepatocellular carcinoma (HCC). Our recent works clarify that Pin1 modulates miRNAs biogenesis by interacting with ERK-phosphorylated exportin-5 (XPO5)and changing XPO5 conformation, giving a potential target for HCC treatment. Herein, we discover 4,6-bis(benzyloxy)-3-phenylbenzofuran (TAB29)as a novel Pin1 inhibitor that targets Pin1 PPIase domain. TAB29 potently inhibits Pin1 activity with the IC50 value of 874 nM and displays an excellent selectivity toward Pin1 in vitro. Cell-based biological evaluation reveals that TAB29 significantly suppresses cell proliferation of HCC cells through restoring the nucleus-to-cytoplasm export of XPO5 and upregulating mature miRNAs expression. Collectively, this work provides a promising small molecule lead compound for Pin1 inhibition, highlighting the therapeutic potential of miRNA-based treatment for human cancers.

Natural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels-Alder reaction: Synthesis and cytotoxicity evaluation

A series of new natural tanshinone-like oxoheterocyclic-fused ortho-quinone derivatives were synthesized from readily available benzofuranol and N-substituted dienes via IBX oxidation-cycloaddition-aromatization procedure. The regiospecific Diels-Alder cycloaddition reactions of N-dienes were achieved efficiently with a variety of dienophiles. It is found that the amide moiety in the molecular could be preserved or eliminated by control of the aromatization conditions. Selected oxoheterocyclic-fused ortho-quinones as well as several thioheterocyclic-fused ortho-quinones we obtained before were evaluated for their cytotoxicities on different cancer cell lines and the Structure-Activity Relationship (SAR) was discussed.

Synthesis and calcium antagonistic activity of a series of diethyl benzofuryl, benzothienyl and benzogammapyronyl benzylphosphonates

In this work we present about 15 original heterocyclic diethyl benzylphosphonate analogues of fostedil, in which we have varied the nature of the heterocycle, the substituents or the phosphonic group, or even the position of this latter.Three diethyl 4-(2