Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.
Wagner, Jared M.,McElhinny Jr., Charles J.,Lewin, Anita H.,Carroll, F. Ivy
p. 2119 - 2125
(2007/10/03)
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