Synthesis and inhibitory effect on platelet aggregation of 2-phenyl-1(2H)-phthalazinone derivatives
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Sugimoto,Sakamoto,Fujino,Takashima,Ishikawa
p. 2809 - 2820
(2007/10/02)
CENTRAL NERVOUS SYSTEM ACTIVE COMPOUNDS. XI. 1-(3-PHTHALIDYL)-PHTHALAZIN-4-ONES
Phthalidylphthalazinones can be readily prepared by the reaction of hydrazines with the corresponding biphthalide.The reaction with unsymmetrical biphthalides appears to be controlled mainly by electronic factors.Phthalidylphthalazinone undergoes the Mannich reaction leading to a 3-substituted product. 1-Chlorophthalazine reacts with butyllithium by addition at C-4; the resulting anion is alkylated at C-3 with methyl 2-formylbenzoate.The compounds cause loss of muscular control mice, but their insolubility hinders further pharmacological investigation.
Prager, Rolf,Ward, A. David,Marshall, Philip,Mooney, Brett