610272-60-1

Upstream product

• 610272-48-5 1-[((E)-3-bromoallyloxy)methyl]benzene 
• 610272-58-7 (2R,3S)-1-benzyloxy-4,4,4-trifluoro-2,3-butanediol 
• 610272-47-4 (E)-(((4,4,4-trifluorobut-2-en-1-yl)oxy)methyl)benzene 
• 610272-59-8 (3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane 

Downstream Products

• 610272-64-5 thiocarbonic acid O-(3-benzyloxy-2-tert-butoxycarbonylamino-1-trifluoromethyl-propyl) ester O-phenyl ester 
• 610272-65-6 (2R)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-4,4,4-trifluorobutane 
• 879292-68-9 (1R,2S)-thioacetic acid S-(2-azido-3-benzyloxy-1-trifluoromethyl-propyl) ester 

Relevant academic research and scientific papers

Regioselective and stereoselective nucleophilic ring opening of trifluoromethylated cyclic sulfates: Asymmetric synthesis of both enantiomers of syn-(3-trifluoromethyl)isoserine

A novel and efficient enantioselective synthesis of both enantiomers of syn-(3-trifluoromethyl)isoserine was achieved. Ring opening of trifluoromethylated cyclic sulfates 3, derived from enantiopure trifluoromethylated vicinal diols 2, with various nucleo

Asymmetric synthesis of both enantiomers of anti-4,4,4-trifluorothreonine and 2-amino-4,4,4-trifluorobutanoic acid

A short and efficient enantio selective synthesis of both enantiomers of anti-4,4,4-trifluorothreonine and 2-amino-4,4,4-trifluorobutanoic acid was successfully developed. Trifluoromethylation of benzyl-protected bromoalkene 4 provided key intermediate trifluoromethylated transdi-substituted alkene 2 in good yield. The sequence then involved Sharpless asymmetric dihydroxylation, nucleophilic opening of cyclic sulfate with NaN3, palladium-catalyzed selective hydrogenation, and oxidation.