The discovery of tertiary-amine LXR agonists with potent cholesterol efflux activity in macrophages
The liver X receptors (LXR) play a key role in cholesterol homeostasis and lipid metabolism. SAR studies around tertiary-amine lead molecule 2, an LXR full agonist, revealed that steric and conformational changes to the acetic acid and propanolamine groups produce dramatic effects on agonist efficacy and potency. The new analogs possess good functional activity, demonstrating the ability to upregulate LXR target genes, as well as promote cholesterol efflux in macrophages.
Marino Jr., Joseph P.,Kallander, Lara S.,Ma, Chun,Oh, Hye-Ja,Lee, Dennis,Gaitanopoulos, Dimitri E.,Krawiec, John A.,Parks, Derek J.,Webb, Christine L.,Ziegler, Kelly,Jaye, Michael,Thompson, Scott K.
scheme or table
p. 5617 - 5621
(2010/04/30)
AMIDE COMPOUNDS AND METHODS OF USING THE SAME
Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
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Page 59
(2010/02/07)
ACID AND ESTER COMPOUNDS AND METHODS OF USING THE SAME
Disclosed is a compound of having the formula (II-A), pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are useful as LXR agonists.
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Page/Page column 33; 46
(2008/06/13)
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