- Preparation method of 3,5-dimethoxy-4-methyl benzoic acid
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The invention discloses a preparation method of 3,5-dimethoxy-4-methyl benzoic acid, which comprises the following steps: adding methyl 4-methyl benzoate in a first organic solvent, adding bromine, and carrying out bromination reaction to obtain methyl 3,
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- Selective para metalation of unprotected 3-methoxy and 3,5-dimethoxy benzoic acids with n-butyl lithium-potassium tert-butoxide (LIC-KOR): Synthesis of 3,5-dimethoxy-4-methyl benzoic acid
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The potassium salt of 3-methoxy and 3,5-dimethoxy benzoic acids undergoes deprotonation at the position para to the carboxylate group selectively when treated with LIC-KOR in THF at -78°C and it has been extended to the synthesis of 3,5-dimethoxy-4-methyl benzoic acid. (C) 2000 Elsevier Science Ltd.
- Sinha, Surajit,Mandal, Bhubaneswar,Chandrasekaran, Srinivasan
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p. 3157 - 3160
(2007/10/03)
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- Process for aromatic ethers
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A process for the preparation of aromatic ethers by the bromination of a compound of the formula STR1 wherein R1, independently, is hydrogen, hydroxy, lower alkoxy, lower alkyl; m is an integer from 1-4, and A is --CHO, --COOR3 or lower alkyl, and subsequently treating the reaction product of the bromination step with an alkali metal alkoxide in the presence of cuprous halide or oxide, is described.
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