Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6- aminopyrimidine inhibitors of cyclin-dependent kinase 2
An efficient synthesis of 2-substituted O4-cyclohexylmethyl-5- nitroso-6-aminopyrimidines from 6-amino-2-mercaptopyrimidin-4-ol has been developed and used to prepare a range of derivatives for evaluation as inhibitors of cyclin-dependent kinas
Marchetti, Francesco,Sayle, Kerry L.,Bentley, Johanne,Clegg, William,Curtin, Nicola J.,Endicott, Jane A.,Golding, Bernard T.,Griffin, Roger J.,Haggerty, Karen,Harrington, Ross W.,Mesguiche, Veronique,Newell, David R.,Noble, Martin E. M.,Parsons, Rachel J.,Pratt, David J.,Wang, Lan Z.,Hardcastle, Ian R.
p. 1577 - 1585
(2008/02/04)
Facilitation of addition-elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol
SNAr displacement reactions of 6-cyclohexylmethoxy-2- fluoropurine, 6-amino-2-butylsulfonyl-4-cyclohexylme-thoxypyrimidine and 2-amino-6-chloropurine with substituted anilines (e.g. the weakly nucleophilic 4-aminobenzenesulfonamide) are dramati
Whitfield, Hayley J.,Griffin, Roger J.,Hardcastle, Ian R.,Henderson, Andrew,Meneyrol, Jerome,Mesguiche, Veronique,Sayle, Kerry L.,Golding, Bernard T.
p. 2802 - 2803
(2007/10/03)
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
A series of O4-cyclohexylmethyl-5-nitroso-6-aminopyrimidines bearing 2-arylamino substituents was synthesised and evaluated for CDK1 and CDK2 inhibitory activity. Consistent with analogous studies with O 6-cyclohexylmethylpurines, 2-
Sayle, Kerry L.,Bentley, Johanne,Boyle, F. Thomas,Calvert, A. Hilary,Cheng, Yuzhu,Curtin, Nicola J.,Endicott, Jane A.,Golding, Bernard T.,Hardcastle, Ian R.,Jewsbury, Philip,Mesguiche, Veronique,Newell, David R.,Noble, Martin E. M.,Parsons, Rachel J.,Pratt, David J.,Wang, Lan Z.,Griffin, Roger J.
p. 3079 - 3082
(2007/10/03)
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