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2-Pyridinecarboxamide, 4-hydroxy-N-methyl(9CI) is a chemical compound with the molecular formula C7H8N2O2. It is an amide derivative of pyridine, featuring a hydroxyl group and a methyl group attached to the nitrogen atom. 2-Pyridinecarboxamide, 4-hydroxy-N-methyl(9CI) is known for its versatile applications in the pharmaceutical industry, particularly as an intermediate in the synthesis of various medicinal agents.

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  • 611226-36-9 Structure
  • Basic information

    1. Product Name: 2-Pyridinecarboxamide, 4-hydroxy-N-methyl- (9CI)
    2. Synonyms: 2-Pyridinecarboxamide, 4-hydroxy-N-methyl- (9CI);4-hydroxy-N-methylpicolinamide;4-Hydroxy-pyridine-2-carboxylic acid methylamide
    3. CAS NO:611226-36-9
    4. Molecular Formula: C7H8N2O2
    5. Molecular Weight: 152.15062
    6. EINECS: N/A
    7. Product Categories: AMIDE;ALCOHOL
    8. Mol File: 611226-36-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 523.3±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.252±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 7.36±0.18(Predicted)
    10. CAS DataBase Reference: 2-Pyridinecarboxamide, 4-hydroxy-N-methyl- (9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-Pyridinecarboxamide, 4-hydroxy-N-methyl- (9CI)(611226-36-9)
    12. EPA Substance Registry System: 2-Pyridinecarboxamide, 4-hydroxy-N-methyl- (9CI)(611226-36-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 611226-36-9(Hazardous Substances Data)

611226-36-9 Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridinecarboxamide, 4-hydroxy-N-methyl(9CI) is used as a key intermediate in the synthesis of a range of medicines, including antituberculosis agents and antipsychotic drugs. Its unique chemical structure allows for the development of therapeutic agents with potential applications in treating various diseases.
Used in Antituberculosis Agents:
In the field of antituberculosis therapy, 2-Pyridinecarboxamide, 4-hydroxy-N-methyl(9CI) serves as a crucial component in the formulation of effective drugs targeting Mycobacterium tuberculosis, the causative agent of tuberculosis.
Used in Antipsychotic Drugs:
2-Pyridinecarboxamide, 4-hydroxy-N-methyl(9CI) is also utilized in the development of antipsychotic medications, which are essential for managing mental health disorders such as schizophrenia and bipolar disorder.
Used in Neurodegenerative Disease Treatment:
2-Pyridinecarboxamide, 4-hydroxy-N-methyl(9CI) has been studied for its potential use in treating neurodegenerative diseases like Parkinson's disease and schizophrenia, due to its neuroprotective properties and ability to modulate various signaling pathways involved in these conditions.
Used in Anti-inflammatory and Neuroprotective Agents:
2-Pyridinecarboxamide, 4-hydroxy-N-methyl(9CI) has been investigated for its role as an anti-inflammatory and neuroprotective agent, making it a compound of interest in the field of medicinal chemistry and drug development. Its potential to alleviate inflammation and protect neurons from damage positions it as a promising candidate for further research and development in therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 611226-36-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,1,2,2 and 6 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 611226-36:
(8*6)+(7*1)+(6*1)+(5*2)+(4*2)+(3*6)+(2*3)+(1*6)=109
109 % 10 = 9
So 611226-36-9 is a valid CAS Registry Number.

611226-36-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N-methyl-4-oxo-1H-pyridine-2-carboxamide

1.2 Other means of identification

Product number -
Other names 4-HYDROXY-N-METHYL-2-PYRIDINECARBOXAMIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:611226-36-9 SDS

611226-36-9Relevant articles and documents

6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS

-

Paragraph 0246; 0247, (2021/11/13)

The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.

Design and synthesis of orally bioavailable benzimidazoles as raf kinase inhibitors

Ramurthy, Savithri,Subramanian, Sharadha,Aikawa, Mina,Amiri, Payman,Costales, Abran,Dove, Jeff,Fong, Susan,Jansen, Johanna M.,Levine, Barry,Ma, Sylvia,McBride, Christopher M.,Michaelian, Jonah,Pick, Teresa,Poon, Daniel J.,Girish, Sandhya,Shafer, Cynthia M.,Stuart, Darrin,Sung, Leonard,Renhowe, Paul A.

supporting information; experimental part, p. 7049 - 7052 (2009/11/30)

A series of arylaminobenzimidazoles was designed and synthesized as Raf kinase inhibitors. Exploration of the structure-activity relationship resulted in compounds that are potent in vitro and show desirable in vivo properties.

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