612041-67-5

Basic information

• Product Name: 4-([(2-FLUOROPHENYL)SULFONYL]AMINO)BENZOIC ACID
• Synonyms: 4-([(2-FLUOROPHENYL)SULFONYL]AMINO)BENZOIC ACID;BENZOIC ACID, 4-[[(2-FLUOROPHENYL)SULFONYL]AMINO]-;4-((2-Fluorophenyl)sulfonamido)benzoic acid
• CAS NO: 612041-67-5
• Molecular Formula: C₁₃H₁₀FNO₄S
• Molecular Weight: 295.29
• Mol File: 612041-67-5.mol

Chemical Properties

• Boiling Point: 488.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.512±0.06 g/cm3(Predicted)
• PKA: 4.01±0.10(Predicted)
• CAS DataBase Reference: 4-([(2-FLUOROPHENYL)SULFONYL]AMINO)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-([(2-FLUOROPHENYL)SULFONYL]AMINO)BENZOIC ACID(612041-67-5)
• EPA Substance Registry System: 4-([(2-FLUOROPHENYL)SULFONYL]AMINO)BENZOIC ACID(612041-67-5)

Safety Data

• Hazardous Substances Data: 612041-67-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-([(2-FLUOROPHENYL)SULFONYL]AMINO)BENZOIC ACID is used as a reagent for the preparation of (phenylsulfonamido)benzoic acid derivatives, which are known for their antifungal and antibacterial activities. These derivatives can be further developed into drugs to combat various fungal and bacterial infections, making this compound a valuable asset in the development of new antimicrobial agents.
Used in Chemical Synthesis:
In the chemical industry, 4-([(2-FLUOROPHENYL)SULFONYL]AMINO)BENZOIC ACID can be utilized as an intermediate in the synthesis of various complex organic molecules. Its unique structure and reactivity make it a versatile building block for creating a wide range of compounds with diverse applications, from pharmaceuticals to specialty chemicals.

Upstream product

• 557097-18-4 C₁₄H₁₂FNO₄S 
• 2905-21-7 2-fluorobenzenesulfonyl chloride 
• 150-13-0 4-amino-benzoic acid 

Relevant articles and documents

Bio-potent sulfonamides

Some 4-(substituted phenylsulfonamido)benzoic acids have been synthesized by fly-ash:H3PO3 nano catalyst catalyzed condensation of substituted benzenesulfonyl chlorides and 4-aminobenzoic acid in ultrasound irradiation conditions. The yields of the sulfonamides are more than 90%. The synthesized 4-(substituted phenylsulfonamido) benzoic acid derivatives were characterized by their physical constants, analytical and spectroscopic data. Antimicrobial activities of all sulfonamides were measured by Bauer-Kirby disc diffusion method.

Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: Effect of sulfonamides P3 substituents on potency and selectivity

Highly potent and selective 4-amidofuran-3-one inhibitors of cathepsin S are described. The synthesis and structure-activity relationship of a series of inhibitors with a sulfonamide moiety in the P3 position is presented. Several members of the series show sub-nanomolar inhibition of the target enzyme as well as an excellent selectivity profile and good cellular potency. Molecular modeling of the most interesting inhibitors describes interactions in the extended S3 pocket and explains the observed selectivity towards cathepsin K.