A DRUG AND SYNTHESIS OF THE DRUG TO TREAT HIGH BLOOD PRESSURE AND TYPE 2 DIABETES MELLITUS DISEASE
The invention relates to a drug and its method of manufacture, which allows to reduce hypertension and treat type 2 diabetes mellitus by using the drug as a dipeptidyl peptidase-4 (DPP-4) inhibitor. The rate of hypoglycemia of the drug in question is low and provides glycemic control and weight loss. The method of manufacturing the mentioned drug includes practical steps to convert the carboxyl group from captopril (1) to the nitrile group.
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Page/Page column 12; 13
(2022/02/28)
A synthesis of captopril through a Baylis-Hillman reaction
A synthesis of the antihipertensive amide 1, named captopril, is described. The strategy is based on a Baylis-Hillman reaction between N-acryloylproline and formaldehyde. Subsequential diaster eoselective hydrogenation step and functional group interconversion provided captopril in good overall yield.
Feltrin, Melissa P.,Almeida, Wanda P.
p. 1141 - 1146
(2007/10/03)
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