- Manufacture of oxalic acid dihydrate
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A process for the manufacture of oxalic acid dihydrate in which an aqueous solution of sodium oxalate is contacted with hydrochloric acid and the resulting mixture then cooled to precipitate oxalic acid, followed by optional recovery and recycling of the sodium oxalate and hydrochloric acid into the reaction chamber.
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Page/Page column 2-3
(2008/06/13)
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- Azetidine, pyrrolidine and piperidine derivatives
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A class of substituted azetidine, pyrrolidine and piperidine derivatives are selective agonists of 5-HT1 -like receptors, being potent agonists of the human 5-HT1Dα receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT1Dα receptor subtype relative to the 5-HT1Dβ subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists.
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- Process for the preparation of hydroxyamines
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A process for the production of hydroxyamines of the formula I wherein R1 and R2 independently of one another are H or CH2 OH and R3 is H, C1 -C4 -alkyl or C1 -C4 -hydroxyalkyl comprising reacting an oxo compound with an amine and reducing the resultant ketimine with a reducing agent.
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