61551-49-3

Basic information

• Product Name: 5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride
• Synonyms: 5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride;6-tetralinsulfonyl chloride;tetralin-6-sulfonyl chloride
• CAS NO: 61551-49-3
• Molecular Formula: C₁₀H₁₁ClO₂S
• Molecular Weight: 230.71114
• Mol File: 61551-49-3.mol

Chemical Properties

• Melting Point: 58°C
• Boiling Point: 341.8 °C at 760 mmHg
• Flash Point: 160.5 °C
• Appearance: /
• Density: 1.2542 (estimate)
• Vapor Pressure: 0.000155mmHg at 25°C
• Refractive Index: 1.571
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride(61551-49-3)
• EPA Substance Registry System: 5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride(61551-49-3)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 61551-49-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride is used as an electrophile in organic synthesis for [application reason]. Its sulfonyl functional group and chloride make it a valuable component in various chemical reactions, contributing to the formation of new compounds and structures.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride is used as a key intermediate in the synthesis of certain drugs and pharmaceutical compounds for [application reason]. Its unique structure and reactivity allow for the development of novel therapeutic agents with specific properties and functions.
Used in Chemical Research:
5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride is used as a research tool in chemical laboratories for [application reason]. Its reactivity and properties make it suitable for studying various chemical reactions and mechanisms, contributing to the advancement of chemical knowledge and understanding.
Used in Specialty Chemicals Production:
5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride is used as a building block in the production of specialty chemicals for [application reason]. Its unique structure and reactivity enable the creation of high-value chemicals with specific applications in various industries, such as coatings, adhesives, and polymers.
Used in Material Science:
In the field of material science, 5,6,7,8-Tetrahydro-2-naphthalenesulfonyl chloride is used as a component in the development of new materials with specific properties for [application reason]. Its incorporation into various materials can lead to improved performance, such as enhanced stability, reactivity, or selectivity in certain applications.

InChI:InChI=1/C10H11ClO2S/c11-14(12,13)10-6-5-8-3-1-2-4-9(8)7-10/h5-7H,1-4H2

Upstream product

• 119-64-2 tetralin 
• 90-15-3 α-naphthol 

Downstream Products

• 101288-99-7 5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid-(N'-phenyl-hydrazide) 
• 213179-53-4 (S)-3-(4-Cyano-phenyl)-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydro-naphthalene-2-sulfonylamino)-propionamide 
• 250723-65-0 3-(4-cyano-2-fluoro-phenyl)-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydro-naphthalene-2-sulfonylamino)-propionamide 
• 250723-64-9 3-(4-cyano-3-fluoro-phenyl)-N-cyclopentyl-N-methyl-2-(5,6,7,8-tetrahydro-naphthalene-2-sulfonylamino)-propionamide 
• 91258-56-9 N-Hydroxy-2-(5,6,7,8-tetrahydro-naphthalen-2-ylsulfanyl)-acetamidine 
• 1089187-42-7 6-(1,2,3,4-tetrahydronaphthalene)-sulfonyl-N-{7-[3-(N-benzyl-N-methyl)-amino-propoxy]-2,3-dihydro-2,2-dimethyl-benzofuran-5-yl}-amide 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

MODULATORS OF CCR9 RECEPTOR AND METHODS OF USE THEREOF

Provided are compounds that are modulators of CCR9 receptor activity, compositions containing the compounds and methods of use of the compounds and compositions. In certain embodiments, provided are methods for treating or ameliorating diseases associated

SUBSTITUTED SULFONAMIDE COMPOUNDS

Substituted sulfonamide derivatives, a process for their preparation, pharmaceutical compositions containing these compounds, and to the use of substituted sulfonamide derivatives in the treatment or inhibition of pain and/or various disorders or disease states.

NEW COMPOUNDS, PROCESS FOR THEIR PREPARATION, INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT OF 5-HT6 MEDIATED DISORDERS SUCH AS ALZHEIMER'S DISEASE, COGNITIVE DISORDERS, COGNITIVE IMPAIRMENT ASSOCIATED WITH SCHIZOPHRENIA, OBESI

The present invention relates to new compounds of formula (I), or salts, solvates or solvated salts thereof, process for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and

Bispiperidines as antithrombotic agents

Novel compounds which are inhibitors of the binding of fibrinogen to the Gp IIb/IIIa platelet receptors, and which can be used therepeutically as antithrombotic agents

Structural modification of an orally active thrombin inhibitor, LB30057: Replacement of the D-pocket-binding naphthyl moiety

An amidrazonophenylalanine derivative LB30057 (2) was identified as a potent (K(i)=0.38nM), selective, and orally active thrombin inhibitor. As a continuation of studies into benzamidrazone-based thrombin inhibitors, we have structurally modified compound 2 by replacing the naphthyl group with a variety of hydrophobic moieties. This study led to discovery of several compounds with significantly enhanced potency in thrombin inhibition without sacrificing selectivity against trypsin and oral absorption. The highest activity was obtained with compound 23 (K(i)=0.045nM). Copyright (C) 1998 Elsevier Science Ltd.