- Synthesis of Highly Substituted Phenols and Benzenes with Complete Regiochemical Control
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Substituted phenols are requisite molecules for human health, agriculture, and diverse synthetic materials. We report a chemical synthesis of phenols, including penta-substituted phenols, that accommodates programmable substitution at any position. This method uses a one-step conversion of readily available hydroxypyrone and nitroalkene starting materials to give phenols with complete regiochemical control and in high chemical yield. Additionally, the phenols can be converted into highly and even fully substituted benzenes.
- Zhang, Xiaojie,Beaudry, Christopher M.
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supporting information
p. 6086 - 6090
(2020/08/12)
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- Catalytic ethylation of phenols
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Alkylation of phenol and cresols with ethanol in the presence of iron-aluminum catalyst was studied.
- Agaev,Shakhtakhtinskaya,Eminov,Guliev
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p. 651 - 653
(2007/10/03)
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