61629-60-5

Basic information

• Product Name: 3-[4-[2-[(5-chloro-2-methoxy-benzoyl)amino]ethyl]phenyl]propanoic acid
• Synonyms: 3-[4-[2-[(5-chloro-2-methoxy-benzoyl)amino]ethyl]phenyl]propanoic acid;HB-093
• CAS NO: 61629-60-5
• Molecular Formula: C₁₉H₂₀ClNO₄
• Molecular Weight: 361.82
• Mol File: 61629-60-5.mol

Chemical Properties

• Boiling Point: 555.1°C at 760 mmHg
• Flash Point: 289.5°C
• Appearance: /
• Density: 1.261g/cm³
• Vapor Pressure: 3.69E-13mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 3-[4-[2-[(5-chloro-2-methoxy-benzoyl)amino]ethyl]phenyl]propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-[2-[(5-chloro-2-methoxy-benzoyl)amino]ethyl]phenyl]propanoic acid(61629-60-5)
• EPA Substance Registry System: 3-[4-[2-[(5-chloro-2-methoxy-benzoyl)amino]ethyl]phenyl]propanoic acid(61629-60-5)

Safety Data

• Hazardous Substances Data: 61629-60-5(Hazardous Substances Data)

Usage

Main properties

1. Chemical compound: 3-[4-[2-[(5-chloro-2-methoxy-benzoyl)amino]ethyl]phenyl]propanoic acid
2. Category: Nonsteroidal anti-inflammatory drugs (NSAIDs)
3. Derivative: Propanoic acid

Specific content

1. Purpose: Used for its anti-inflammatory, analgesic, and antipyretic properties
2. Mechanism of action: Inhibits the production of prostaglandins, which are mediators of inflammation and pain
3. Uses: Effective in the treatment of conditions such as arthritis, menstrual pain, and fever
4. Chemical structure: Contains a 5-chloro-2-methoxy-benzoyl group
5. Mode of action: Targets certain enzymes involved in the inflammatory process

InChI:InChI=1/C19H20ClNO4/c1-25-17-8-7-15(20)12-16(17)19(24)21-11-10-14-4-2-13(3-5-14)6-9-18(22)23/h2-5,7-8,12H,6,9-11H2,1H3,(H,21,24)(H,22,23)

Upstream product

• 61629-86-5 (E)-3-{4-[2-(5-Chloro-2-methoxy-benzoylamino)-ethyl]-phenyl}-acrylic acid 
• 61629-90-1 ethyl β-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride 
• 29568-33-0 2-methoxy-5-chlorobenzoyl chloride 
• 73918-56-6 4-Bromophenethylamine 
• 120157-97-3 t-butyl 2-(4-bromophenyl)ethylcarbamate 
• 64506-98-5 methyl 3-(4-(2-(5-chloro-2 methoxybenzamido)ethyl)phenyl)propanoate 
• 61630-20-4 5-chloro-2-methoxy-N-(2-<4-formylphenyl>-ethyl)-benzamide 

Downstream Products

• 64506-98-5 methyl 3-(4-(2-(5-chloro-2 methoxybenzamido)ethyl)phenyl)propanoate 
• 64506-81-6 3-(3-{4-[2-(5-Chloro-2-methoxy-benzoylamino)-ethyl]-phenyl}-propionylamino)-propionic acid 
• 64506-80-5 2-(3-{4-[2-(5-Chloro-2-methoxy-benzoylamino)-ethyl]-phenyl}-propionylamino)-3-phenyl-propionic acid 
• 78445-35-9 4-(3-{4-[2-(5-Chloro-2-methoxy-benzoylamino)-ethyl]-phenyl}-propionylamino)-benzoic acid ethyl ester 
• 64506-79-2 2-(3-{4-[2-(5-Chloro-2-methoxy-benzoylamino)-ethyl]-phenyl}-propionylamino)-benzoic acid 
• 64506-78-1 N-{{β-{4-[2-(5-Chloro-2-methoxybenzamido)-ethyl]-phenyl}-propionyl}}-p-aminobenzoic acid 

Relevant articles and documents

Preparation of phenylethylbenzamide derivatives as modulators of DNMT3 activity

DNA-methyltransferases (DNMTs) are a class of epigenetic enzymes that catalyze the transfer of a methyl moiety from the methyl donor S-adenosyl-l-methionine onto the C5 position of cytosine in DNA. This process is dysregulated in cancers and leads to the hypermethylation and silencing of tumor suppressor genes. The development of potent and selective inhibitors of DNMTs is of utmost importance for the discovery of new therapies for the treatment of cancer. We report herein the synthesis and DNMT inhibitory activity of 29 analogues derived from NSC 319745. The effect of selected compounds on the methylation level in the MDA-MB-231 human breast cancer cell line was evaluated using a luminometric methylation assay. Molecular docking studies have been conducted to propose a binding mode for this series.

Hypoglycemically and hypolipidemically active derivatives of phenyl-alkane-carboxylic acids

Phenyl-alkane-carboxylic acids of the formula STR1 wherein A is an aryl, aralkyl or arylvinyl radical optionally substituted by hydroxy, halogen, trifluoromethyl, alkyl, alkylthio, alkoxy, alkenyloxy, alkoxyalkoxy, alkyl-substituted amino, aryloxy or alkoxy-substituted aryloxy, or is an aryloxyalkyl or arylthioalkyl radical, or a heterocyclic ring system optionally substituted by halogen, alkyl or alkoxy, Y is a valency bond or an unbranched or branched lower alkylene radical containing up to 3 carbon atoms, X is a straight or branched, saturated or unsaturated divalent aliphatic hydrocarbon radical containing 2 to 8 carbon atoms, there being at least 2 carbon atoms between the benzene ring and the carboxyl group, and R is a hydrogen atom or a lower alkyl radical, as well as physiologically compatible salts, esters and amides thereof, exhibit hypoglycaemic and hypolipidaemic activity.