- Production process of 2-ethoxy-4, 6-difluoropyrimidine
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The invention discloses a synthesis method of 2-ethoxy-4, 6-difluoropyrimidine, which comprises the following steps: (1) reacting urea with diethyl sulfate in an organic solvent at 60-120 DEG C to prepare an intermediate I; (2) synthesizing an intermediate II from the intermediate I and diethyl malonate; (3) performing chlorination on the intermediate II to obtain an intermediate III; and (4) reacting the intermediate III with a fluorinated reagent at 80-120 DEG C for 6 hours, and performing separation and purification to obtain the target product 2-ethoxy-4, 6-difluoropyrimidine, which has astructure described in the specification. The initial raw material urea adopted by the invention is low in price and easy to obtain, the production cost is low, the reaction process is simple and reasonable, the production safety is high, the operation is simple, and the method is suitable for industrial large-scale production.
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Paragraph 0027-0029
(2020/07/15)
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- Pyrimidine (4,6)diyl-bis-(thiono)(thiol)-phosphoric(phosphonic)acid esters
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Pyrimidine (4,6)diyl-bis-(thiono)(thiol)-phosphoric (phosphonic) acid esters of the formula STR1 in which R is alkyl with 1 to 6 carbon atoms, R1 is alkyl, alkoxy or alkylmercapto each with 1 to 6 carbon atoms or phenyl, R2 is alkyl, alkoxy or alkylmercapto each with 1 to 5 carbon atoms, hydrogen or phenyl, R3 is hydrogen, alkyl with 1 to 4 carbon atoms or halogen, and X is oxygen or sulfur, Which possess insecticidal and acaricidal properties.
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