- Visible-light-mediated multicomponent reaction for secondary amine synthesis
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The widespread presence of secondary amines in agrochemicals, pharmaceuticals, natural products, and small-molecule biological probes has inspired efforts to streamline the synthesis of molecules with this functional group. Herein, we report an operationally simple, mild protocol for the synthesis of secondary amines by three-component alkylation reactions of imines (generated in situ by condensation of benzaldehydes and anilines) with unactivated alkyl iodides catalyzed by inexpensive and readily available Mn2(CO)10. This protocol, which is compatible with a wide array of sensitive functional groups and does not require a large excess of the alkylating reagent, is a versatile, flexible tool for the synthesis of secondary amines.
- Wang, Xiaochen,Zhu, Binbing,Dong, Jianyang,Tian, Hao,Liu, Yuxiu,Song, Hongjian,Wang, Qingmin
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supporting information
p. 5028 - 5031
(2021/05/28)
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- Copper-Catalyzed and Indium-Mediated Methoxycarbonylation of Unactivated Alkyl Iodides with Balloon CO
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This work emphasizes the synthesis of alkyl esters via Cu-catalyzed and In-mediated alkoxycarbonylation of unactivated alkyl iodides in the presence of In or InI. The reactions were suitable for the preparation of primary, secondary, and even tertiary alkyl esters, representing an exceptionally rare example for the creation of quaternary carbon centers upon formation of esters. The preliminary mechanistic studies indicated that alkyl radicals were involved, and Cu/In/CO played a cooperative role in the carbonylation event.
- Chen, Yanchi,Su, Lei,Gong, Hegui
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p. 4689 - 4693
(2019/06/27)
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- Iodination of alcohols using triphenylphosphine/iodine under solvent-free conditions using microwave irradiation
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A straightforward and effective procedure for the conversion of benzylic, allylic and aliphatic alcohols to the corresponding iodides using Ph3P/I2 under solvent-free conditions using microwave irradiation is reported.
- Hajipour, Abdol Reza,Falahati, Ali Reza,Ruoho, Arnold E.
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p. 4191 - 4196
(2007/10/03)
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- An intriguing hydroiodination of alkenes and alkynes with titanium tetraiodide
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Olefins and acetylenes were hydroiodinated with titanium tetraiodide to give alkyl iodides, vinyl iodides, and alkyl diiodides in good yields. In the presence of acetals, the reaction gave intriguing C-C bond-forming products. Georg Thieme Verlag Stuttgart.
- Shimizu, Makoto,Toyoda, Tadahiro,Baba, Toru
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p. 2516 - 2518
(2007/10/03)
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