Design and synthesis of novel pyrrolidine-containing bradykinin antagonists
The design and synthesis of novel pyrrolidine-containing bradykinin antagonists, II, are described. Conformational analysis suggested that a pyrrolidine moiety could substitute for the N-methyl cis-amide moiety of FR 173657. The in vitro binding data show
Lee, Jung,Reynolds, Charles,Jetter, Michele C.,Youngman, Mark A.,Hlasta, Dennis J.,Dax, Scott L.,Stone, Dennis J.,Zhang, Sui-Po,Codd, Ellen E.
p. 1879 - 1882
(2007/10/03)
NOVEL HETEROARYL ALKYLAMIDE DERIVATIVES USEFUL AS BRADYKININ RECEPTOR MODULATORS
This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and allergy. Furthermore, the present invention is directed to novel alkylamide derivatives as bradykinin receptor agonists useful for the treatment of bradykinin modulated disorders such as hypertension and the like.
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Page/Page column 102-103
(2010/02/07)
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