618084-59-6

Basic information

• Product Name: 5,7-DiMethoxy-3-Methyl-2,3-dihydro-1H-inden-1-one
• Synonyms: 5,7-DiMethoxy-3-Methyl-2,3-dihydro-1H-inden-1-one
• CAS NO: 618084-59-6
• Molecular Formula: C12H14O3
• Molecular Weight: 206.23776
• Mol File: 618084-59-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5,7-DiMethoxy-3-Methyl-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DiMethoxy-3-Methyl-2,3-dihydro-1H-inden-1-one(618084-59-6)
• EPA Substance Registry System: 5,7-DiMethoxy-3-Methyl-2,3-dihydro-1H-inden-1-one(618084-59-6)

Safety Data

• Hazardous Substances Data: 618084-59-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5,7-DiMethoxy-3-Methyl-2,3-dihydro-1H-inden-1-one is used as a chemical intermediate for the synthesis of various organic compounds, contributing to the development of new pharmaceutical products.
Used in Chemical Industry:
In the chemical industry, 5,7-DiMethoxy-3-Methyl-2,3-dihydro-1H-inden-1-one serves as a building block in the production of other chemicals, facilitating the creation of a wide range of chemical products.

Upstream product

• 89981-17-9 3,5-dimethoxy-1-phenylmagnesium chloride 
• 618084-32-5 5-[1-(3,5-dimethoxyphenyl)ethyl]-2,2-dimethyl-1,3-dioxane-4,6-dione 

Relevant articles and documents

Meldrum's acids as acylating agents in the catalytic intramolecular Friedel-Crafts reaction

(Chemical Equation Presented) The intramolecular Friedel-Crafts acylation of aromatics with Meldrum's acid derivatives catalyzed by metal trifluoromethanesulfonates is reported. Meldrum's acids are easily prepared, functionalized, handled, and purified. The synthesis of polysubstituted 1-indanones from benzyl Meldrum's acids was investigated thoroughly, and it was shown that a variety of catalysts were effective, while accommodating a diversity of functional groups under mild conditions. The scope, limitations, and functional group tolerance (terminal alkene and alkyne, ketal, dialkyl ether, dialkyl thioether, aryl methyl ether, aryl TIPS and TBDPS ethers, nitrile- and nitro-substituted aryls, alkyl and aryl halides) for a variety of 5-benzyl (enolizable Meldrum's acids) and 5-benzyl-5-substituted Meldrum's acids (quaternized Meldrum's acids), forming 1-indanones and 2-substituted-1- indanones, respectively, are delineated. This method was further applied to the synthesis of 1-tetralones, 1-benzosuberones, and the potent acetylcholinesterase inhibitor donepezil. Rate of cyclization as a function of ring size was established for various benzocyclic ketones via competition experiments: 1-tetralones form faster than both 1-indanones and 1-benzosuberones, and 1-benzosuberones cyclize faster than 1-indanones.

Convenient Access to Polysubstituted 1-Indanones by Sc(OTf) 3-Catalyzed Intramolecular Friedel-Crafts Acylation of Benzyl Meldrum's Acid Derivatives

(Matrix presented) The intramolecular Friedel-Crafts acylation of benzyl Meldrum's acids is catalyzed by Sc(OTf)3 under mild reaction conditions. Several polysubstituted 1-indanones have been prepared.