- Organocatalytic asymmetric [4+2] cyclization of 2-benzothiazolimines with azlactones: Access to chiral benzothiazolopyrimidine derivatives
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An organocatalytic asymmetric domino Mannich/cyclization reaction between 2-benzothiazolimines with azlactones has been successfully developed. With the bifunctional squaramide catalyst, this formal [4+2] cyclization occurs with good to high yields and excellent stereoselectivities (up to 99% ee, >20?:?1 dr), providing an efficient and mild access to chiral benzothiazolopyrimidines bearing adjacent tertiary and quaternary stereogenic centers.
- Ni, Qijian,Wang, Xuyang,Xu, Fangfang,Chen, Xiaoyun,Song, Xiaoxiao
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supporting information
p. 3155 - 3158
(2020/03/23)
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- Access to Amide from Aldimine via Aerobic Oxidative Carbene Catalysis and LiCl as Cooperative Lewis Acid
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Herein, an efficient route to amides from aldimines via aza-Breslow intermediates through aerobic oxidative carbene catalysis with LiCl as a cooperative Lewis acid is described. Many of the obtained N-heteroarylamides feature biological activity. Ambient
- Wang, Guanjie,Fu, Zhenqian,Huang, Wei
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supporting information
p. 3362 - 3365
(2017/07/13)
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- Synthesis of Imidazo[2,1-b]thiazoles via Copper-Catalyzed A3-Coupling in Batch and Continuous Flow
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A straightforward method for the synthesis of functionalized imidazo[2,1-b]thiazoles starting from benzaldehydes, 2-aminothiazoles, and alkynes under copper(I,II) catalysis was developed. The protocol allows the construction of a variety of aryl-substituted imidazo[2,1-b]benzothiazoles, -[2,1-b]thiazoles, and -[2,1-b][1,3,4]thiadiazoles. The reactions were easy to perform affording most of the desired products in 33-93% yields. The intensification of the process in a continuous-flow reactor increases the products' yields up to quantitative.
- Rassokhina, Irina V.,Tikhonova, Tatyana A.,Kobylskoy, Sergey G.,Babkin, Igor Yu.,Shirinian, Valerii Z.,Gevorgyan, Vladimir,Zavarzin, Igor V.,Volkova, Yulia A.
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p. 9682 - 9692
(2017/09/23)
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- Ultrasound-assisted one-pot synthesis of bis-azetidinones in the presence of zeolite
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Sonochemical method is an innovative task for the sustainable chemical research industry. In this work, an attempt was made to synthesize bis-azetidin-2-ones (2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j) by Staudinger reaction ([2 + 2] ketene-imine cycloadditi
- Jetti, Venkateshwarlu,Chidurala, Praveen,Pagadala, Ramakanth,Meshram, Jyotsna S.,Ramakrishna, Chowdam
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p. E183-E188
(2014/11/08)
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- Synthesis and biological significance of 2-aminobenzothiazole derivatives
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Several new 2-N-(substituted benzyledine)-imino-1,3-benzothiazole 1; 2-[2′-(substituted phenyl)-4′-oxo-1′,3′-thiazolidine]-1, 3-benzothiazole 2 and 2-[5′-(arylidene)-2′-substituted phenyl-4′-oxo-1′,3′-thiazolidine]-1,3-benzothiazole 3 have been synthesize
- Srivastava,Shukla
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experimental part
p. 306 - 309
(2009/05/31)
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- ELECTRON IMPACT MASS SPECTRA OF para-SUBSTITUTED N-HETEROARYL BENZYLAMINES
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The 70 eV electron impact mass spectra of some para-substituted N-heteroaryl benzylamines, synthesized through the corresponding Schiff bases, are reported.Typical fragmentation patterns are discussed with the aid of mass analyzed ion kinetic energy spectra and exact mass measurements.The compounds are relatively stable under electron impact, the molecular ion being the base peak or the second most intense ion in the spectra.The dominating breakdown process is the benzylic cleavage, that gives rise to the base peak in some of the investigated compounds and to the second intense peak in others.
- Fioravanti, Rossella,Biava, Mariangela,Poretta, Giulio Cesare,Foti, Salvatore,Masumarra, Giuseppe,Saletti, Rosaria
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p. 367 - 378
(2007/10/02)
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