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8-methoxy-5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

618910-07-9

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618910-07-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 618910-07-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,1,8,9,1 and 0 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 618910-07:
(8*6)+(7*1)+(6*8)+(5*9)+(4*1)+(3*0)+(2*0)+(1*7)=159
159 % 10 = 9
So 618910-07-9 is a valid CAS Registry Number.

618910-07-9Downstream Products

618910-07-9Relevant articles and documents

Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1 H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators

Brindani, Nicoletta,Gianotti, Ambra,Giovani, Simone,Giacomina, Francesca,Di Fruscia, Paolo,Sorana, Federico,Bertozzi, Sine Mandrup,Ottonello, Giuliana,Goldoni, Luca,Penna, Ilaria,Russo, Debora,Summa, Maria,Bertorelli, Rosalia,Ferrera, Loretta,Pesce, Emanuela,Sondo, Elvira,Galietta, Luis J. V.,Bandiera, Tiziano,Pedemonte, Nicoletta,Bertozzi, Fabio

, p. 11169 - 11194 (2020/10/09)

Cystic fibrosis (CF) is a life-threatening autosomal recessive disease, caused by mutations in the CF transmembrane conductance regulator (CFTR) chloride channel. CFTR modulators have been reported to address the basic defects associated with CF-causing mutations, partially restoring the CFTR function in terms of protein processing and/or channel gating. Small-molecule compounds, called potentiators, are known to ameliorate the gating defect. In this study, we describe the identification of the 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole core as a novel chemotype of potentiators. In-depth structure-activity relationship studies led to the discovery of enantiomerically pure 39 endowed with a good efficacy in rescuing the gating defect of F508del-and G551D-CFTR and a promising in vitro druglike profile. The in vivo characterization of γ-carboline 39 showed considerable exposure levels and good oral bioavailability, with detectable distribution to the lungs after oral administration to rats. Overall, these findings may represent an encouraging starting point to further expand this chemical class, adding a new chemotype to the existing classes of CFTR potentiators.

γ-Carbolines: Binding at 5-HT5A serotonin receptors

Khorana, Nantaka,Purohit, Anil,Herrick-Davis, Katherine,Teitler, Milt,Glennon, Richard A.

, p. 717 - 722 (2007/10/03)

Screening of various agents resulted in the identification of 5-methyl-1,2,3,4-tetrahydro-γ-carboline (1; Ki=5,300 nM) as a compound with modest affinity for mouse 5-HT5A receptors. Structure-affinity studies were conducted resulting

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