Generation of stable synthetic equivalents of unstable α-alkoxyacetaldehydes: An improved preparation of dirithromycin
Described is the in situ preparation of the hemiacetals of α-alkoxyacetaldehydes. The hemiacetals are generated by hydrolysis of an acetal precursor in aqueous acetonitrile solutions. These hemiacetals serve as stable aldehyde equivalents, thus circumventing the production and isolation of unstable α-alkoxyaldehydes. The hemiacetal of 2-methoxyethoxyacetaldehyde is utilized in an effective and efficient preparation of Dirithromycin (LY237216).
McGill
p. 1089 - 1091
(2007/10/02)
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