Palladium-Catalyzed Polyhetero-Claisen Rearrangement of 2-(Allylthio)pyrimidin-4(3H)-ones
The regioselective S -> N allylic transposition of 2-(allylthio)pyrimidin-4(3H)-ones (3) has been performed by catalysis of Pd(II) salts.Generally the rearrangement gives the N-1 alkylation product predominantly over the N-3-alkylation product.Substituents at the 6-position of 3 reverse the selectivity.Both N-1 and N-3 rearrangement products were transformed to thiazolopyrimidones.