62093-17-8Relevant articles and documents
Metal-free directed C?H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines
Chen, Lu,Ji, Yafei,Ma, Tao,Pang, Binghan,Wang, Shuai,Wu, Gaorong,Xu, Xiaobo
supporting information, (2021/11/04)
A novel method for metal-free C?H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines has been reported. The 5-fluoropyridine directed borylation reaction exhibited high efficiency and site exclusivity. The useful protocol could be executed on a gram-scale easily and the borylated products showed good derivatization applications. Moreover, the practicality of the strategy was expanded by the fact that the directing group could be removed in an acceptable yield.
Nickel-Catalyzed Intramolecular Desulfitative C - N Coupling: A Synthesis of Aromatic Amines
Chen, Xuemeng,Jia, Xiuwen,Kramer, S?ren,Li, Yue,Lian, Zhong,Liu, Jiangjun,Sun, Haotian
, p. 5702 - 5711 (2020/05/19)
A nickel-catalyzed intramolecular C - N coupling reaction via SO2 extrusion is presented. The use of a catalytic amount of BPh3 allows the transformation to take place under much milder conditions (60 °C) than previously reported C - N coupling reactions by CO or CO2 extrusion (160-180 °C). In addition, this method displays good functional group tolerance and versatility, as it can be applied to the synthesis of dialkyl aryl amines, alkyl diaryl amines, and triaryl amines. The robustness of the desulfitative C - N coupling is demonstrated by three high-yielding gram-scale reactions.
Palladate Precatalysts for the Formation of C-N and C-C Bonds
Zinser, Caroline M.,Warren, Katie G.,Nahra, Fady,Al-Majid, Abdullah,Barakat, Assem,Islam, Mohammad Shahidul,Nolan, Steven P.,Cazin, Catherine S. J.
, p. 2812 - 2817 (2019/08/12)
A series of imidazolium-based palladate precatalysts has been synthesized and the catalytic activity of these air- and moisture-stable complexes evaluated as a function of the nature of the imidazolium counterion. These precatalysts can be converted under
A Highly Active Ylide-Functionalized Phosphine for Palladium-Catalyzed Aminations of Aryl Chlorides
Weber, Philip,Scherpf, Thorsten,Rodstein, Ilja,Lichte, Dominik,Scharf, Lennart T.,Goo?en, Lukas J.,Gessner, Viktoria H.
supporting information, p. 3203 - 3207 (2019/01/09)
Ylide-functionalized phosphine ligands (YPhos) were rationally designed to fit the requirements of Buchwald–Hartwig aminations at room temperature. This ligand class combines a strong electron-donating ability comparable to NHC ligands with high steric demand similar to biaryl phosphines. The active Pd species are stabilized by agostic C?H???Pd rather than by Pd–arene interactions. The practical advantage of YPhos ligands arises from their easy and scalable synthesis from widely available, inexpensive starting materials. Benchmark studies showed that YPhos-Pd complexes are superior to the best-known phosphine ligands in room-temperature aminations of aryl chlorides. The utility of the catalysts was demonstrated by the synthesis of various arylamines in high yields within short reaction times.
Pd-PEPPSI-IPentAn Promoted Deactivated Amination of Aryl Chlorides with Amines under Aerobic Conditions
Huang, Fei-Dong,Xu, Chang,Lu, Dong-Dong,Shen, Dong-Sheng,Li, Tian,Liu, Feng-Shou
, p. 9144 - 9155 (2018/07/21)
We report herein a highly efficient Pd-catalyzed amination by "bulky-yet-flexible" Pd-PEPPSI-IPentAn complexes. The relationship between the N-heterocyclic carbenes (NHCs) structure and catalytic properties was discussed. Sterically hindered (hetero)aryl chlorides and a variety of aliphatic and aromatic amines can be applied in this cross-coupling, which smoothly proceeded to provide desired products. The operationally simple protocol highlights the rapid access to CAr-N bond formation under mild conditions without the exclusion of air and moisture.
[Pd(IPr*R)(acac)Cl]: Efficient bulky Pd-NHC catalyst for Buchwald-Hartwig C-N cross-coupling reaction
Tian, Xiabing,Lin, Jing,Zou, Sheng,Lv, Junwei,Huang, Qingfei,Zhu, Jin,Huang, Shuping,Wang, Qiwei
supporting information, p. 125 - 130 (2018/03/06)
A series of bulky palladium catalysts based on N-heterocyclic carbene, (Pd(NHC)(acac)Cl: NHC = IPr*me = N,N′-bis(2,6-bis(di-p-tolylmethyl)-4-methylphenyl)-imidazol-2 -ylidene, Pd(IPr*me)(acac)Cl; NHC = IPr*ipr = N,N′-bis(2,6-bis(di-4-isopropylphenyl)-4-methylphenyl)-imidazol-2 -ylidene, Pd(IPr*ipr)(acac)Cl; and NHC = IPr*tBu = N,N′-bis(2,6-bis(di-4-(tert-butyl)phenyl)- 4-methylphenyl)- imidazol-2-ylidene, Pd(IPr*tBu)(acac)Cl; acac = acetylacetonate), have been designed and synthesized. These three new catalysts showed much better catalytic activity in the Buchwald?Hartwig arylamination coupling reaction as compare to the earlier congener (IPr*)Pd(acac)Cl (IPr* = N,N′-bis(2,6-diphenylmethyl)-4-methylphenylimidazol-2-ylidene). The highly active PdII precatalyst [Pd(IPr*me)(acac)Cl] has been fully explored by using a wide range of substrates with different electronic and steric demands of coupling partners, for which up to 99% isolated yields were obtained. Remarkably, the moderate isolated yield was obtained for the challenging coupling of the amine bearing very bulky groups.
Application of a 2-aryl indenylphosphine ligand in the Buchwald-Hartwig cross-coupling reactions of aryl and heteroaryl chlorides under the solvent-free and aqueous conditions
Liu, Yan,Yuan, Jia,Wang, Zi-Fei,Zeng, Si-Hao,Gao, Meng-Yue,Ruan, Mei-Lin,Chen, Jian,Yu, Guang-Ao
supporting information, p. 5805 - 5810 (2017/07/22)
An efficient solvent-free protocol for the Buchwald-Hartwig cross-coupling reaction of aryl and heteroaryl chlorides with primary and secondary amines using the Pd(dba)2/ligand 1 catalytic system has been developed. Notably, the catalytic system also efficiently catalyzed the reaction under aqueous conditions.
A Chemoselective N-Arylation Reaction of 2-Aminopyridine Derivatives with Arynes
Cheng, Bin,Wei, Jian,Zu, Bing,Zhao, Jianfei,Wang, Taimin,Duan, Xiaoguang,Wang, Renqi,Li, Yun,Zhai, Hongbin
, p. 9410 - 9417 (2017/09/23)
A chemoselective N-arylation reaction of 2-aminopyridine derivatives with arynes in good to excellent yields has been described. The N-arylation products could be further applied to the facile construction of benzoisoquinuclidines and isoquinuclidines as
Synthesis of Amidines from Amides Using a Nickel-Catalyzed Decarbonylative Amination through CO Extrusion Intramolecular Recombination Fragment Coupling
Liu, Xiangqian,Yue, Huifeng,Jia, Jiaqi,Guo, Lin,Rueping, Magnus
supporting information, p. 11771 - 11775 (2017/09/07)
A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.
Structural diversity of phenoxy functionalized triazol-5-ylidene palladium(II) complexes and their application in C-N bond formation
Mendoza-Espinosa, Daniel,González-Olvera, Rodrigo,Osornio, Cecilia,Negrón-Silva, Guillermo E.,álvarez-Hernández, Alejandro,Bautista-Hernández, Claudia I.,Suárez-Castillo, Oscar R.
supporting information, p. 142 - 149 (2016/01/12)
The preparation and isolation of a variety of mono-, bis-, and heteroleptic mesoionic triazol-5-ylidene palladium(II) complexes is reported. Treatment of phenoxy functionalized triazolium salts [Bn-MIC(H)]+I- (1) and [Mes-MIC(H)]+I- (2) with half equivalent of palladium acetate, produced complexes 3 and 4 with a general structure of [(MIC)2Pd(I)2] as isomeric cis/trans mixtures. When the reaction of palladium acetate and the cationic precursors was carried out with equimolar amounts in presence of sodium iodide, the μ2-I2 bridged complexes 5 and 6 of the type [(MIC)PdI2]2 were obtained as unique products. Additionally, the preparation of the heteroleptic PEPPSI-type complexes ([Py(PdI2)MIC]) 7 and 8 was readily achieved by the thermal treatment of the triazolium precursors with PdCl2, K2CO3, and sodium iodide in pyridine. All complexes have been fully characterized by 1H and 13C NMR, FT-IR, elemental analysis, and in the case of 2, 3trans, 6, and 7 single crystal X-ray diffraction. Preliminary catalytic results with the palladium series established the enhanced performance of PEPPSI complexes 7 and 8 in the Buchwald-Hartwing catalyzed formation of C-N bonds between aryl halides and primary/secondary amines under mild reaction conditions.
