620985-09-3

Basic information

• Product Name: 4(1H)-Pyrimidinone, 6-hydroxy-2-(phenoxymethyl)- (9CI)
• Synonyms: 4(1H)-Pyrimidinone, 6-hydroxy-2-(phenoxymethyl)- (9CI)
• CAS NO: 620985-09-3
• Molecular Formula: C₁₁H₁₀N₂O₃
• Molecular Weight: 218.2087
• Product Categories: ALCOHOL
• Mol File: 620985-09-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4(1H)-Pyrimidinone, 6-hydroxy-2-(phenoxymethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Pyrimidinone, 6-hydroxy-2-(phenoxymethyl)- (9CI)(620985-09-3)
• EPA Substance Registry System: 4(1H)-Pyrimidinone, 6-hydroxy-2-(phenoxymethyl)- (9CI)(620985-09-3)

Safety Data

• Hazardous Substances Data: 620985-09-3(Hazardous Substances Data)

Upstream product

• 108-13-4 malonodiamide 
• 2555-49-9 phenoxyacetic acid ethyl ester 

Downstream Products

• 1260235-93-5 C₁₆H₁₄N₂O₄ 

Relevant articles and documents

Discovery of a potent nicotinic acid receptor agonist for the treatment of dyslipidemia

Nicotinic acid has been used clinically for decades to control serum lipoproteins. Nicotinic acid lowers very low-density lipoprotein (VLDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, and lipoprotein-a (LPa), and it is also effective in raising high-density lipoprotein (HDL)-cholesterol. However, nicotinic acid has several side effects in clinical use. The most notable is intense cutaneous vasodilation "flushing"+ on the upper body and face. We discovered a pyranopyrimidinedione series to be nicotinic acid receptor agonists. A potent nicotinic acid receptor agonist from this series {5-(3-cyclopropylpropyl)-2-(difluoromethyl)-3H-pyrano[2,3-d] pyrimidine-4,7-dione}with reduced flushing side effect in dogs was identified.

4-AMINO-PYRIMIDINE DERIVATIVES

4-Amino-pyrimidine derivatives of Formula (I), wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine H4 receptor antagonists.