- INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF
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The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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- 3,4-DISUBSTITUTED 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK
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The present invention relates to the use of novel compounds of formula (I), wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.
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Page/Page column 39
(2014/05/24)
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- PDE10 MODULATORS
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The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.
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Paragraph 0515-0516
(2013/03/26)
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- PDE10 MODULATORS
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The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.
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Page/Page column 88
(2013/03/26)
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- ETHYL CARBOETHOXYFORMIMIDATE IN HETEROCYCLIC CHEMISTRY
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The reactions of ethyl carboethoxyformimidate with various bidentate reagents illustrate its usefulness as a reagent in heterocyclic chemistry.
- Gomez, E.,Avendano, C.,McKillop, A.
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p. 2625 - 2634
(2007/10/02)
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