- Visible light-mediated C-H difluoromethylation of electron-rich heteroarenes
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A novel method for visible-light photoredox-catalyzed difluoromethylation of electron-rich N-, O-, and S-containingheteroarenes under mild reaction conditions is developed. Mechanistic investigation indicates that the net C-H difluoromethylation proceeds through an electrophilic radical-type pathway.
- Su, Yi-Ming,Hou, Yu,Yin, Feng,Xu, Yue-Ming,Li, Yan,Zheng, Xiaoqi,Wang, Xi-Sheng
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supporting information
p. 2958 - 2961
(2014/06/23)
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- Novel derivatives of 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles and their pharmacological evaluation as CB1 cannabinoid ligands
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In a previous study, we have identified 3-alkyl-1,5-diaryl-1H-1,2,4- triazoles to be a novel class of cannabinoid type-1 (CB1) receptor antagonists. However, the synthesis yields for the ligands were low. Here we present an alternative synthesi
- Hernandez-Folgado, Laura,Goya, Pilar,Frigola, Jordi,Cuberes, Maria Rosa,Dordal, Alberto,Holenz, Joerg,Jagerovic, Nadine
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experimental part
p. 1073 - 1082
(2009/10/24)
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