Synthesis and bioevaluation of glycosyl ureas as α-glucosidase inhibitors and their effect on mycobacterium
Glycosyl amino esters (2-13) on reaction with different isocyanates resulted in quantitative conversion to glycosyl ureas (14 - 32). Few of the selected ureas (15-20, 22-28, 30 and 32) on cyclative amidation with DBU/TBAB/4 A MS gave respective dihydropyrimidinones in fair to good yields (33-47). The compounds were screened for α-glucosidase inhibitory activity and two (19 and 23) of them showed strong inhibition against rat intestinal α-glucosidase. The compounds were also screened against Mycobacterium aurum, however, only one (19) of them exhibited marginal antitubercular activity.
Get Best Price for623559-48-8ethyl [(1R,2R,3S,4R,5S)-5,6-dideoxy-1,2-O-isopropylidene-3-O-methyl-5-(N1-hexadecyl-N3-phenyl-1-ureidyl)-1,4-heptofuranos-5-yl]uronoate