623564-43-2

Basic information

• Product Name: 8H-Imidazo[2,1-c][1,4]oxazine-3-carboxaldehyde, 5,6-dihydro- (9CI)
• Synonyms: 8H-Imidazo[2,1-c][1,4]oxazine-3-carboxaldehyde, 5,6-dihydro- (9CI);6,8-Dihydro-5H-imidazo[2,1-c][1,4]oxazine-3-carbaldehyde
• CAS NO: 623564-43-2
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15062
• Product Categories: ALDEHYDE;AMINETERTIARY
• Mol File: 623564-43-2.mol

Chemical Properties

• Boiling Point: 413.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.33±0.20(Predicted)
• CAS DataBase Reference: 8H-Imidazo[2,1-c][1,4]oxazine-3-carboxaldehyde, 5,6-dihydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 8H-Imidazo[2,1-c][1,4]oxazine-3-carboxaldehyde, 5,6-dihydro- (9CI)(623564-43-2)
• EPA Substance Registry System: 8H-Imidazo[2,1-c][1,4]oxazine-3-carboxaldehyde, 5,6-dihydro- (9CI)(623564-43-2)

Safety Data

• Hazardous Substances Data: 623564-43-2(Hazardous Substances Data)

Upstream product

• 623564-41-0 morpholin-3-ylideneamine hydrochloride 
• 155272-73-4 2-bromo-3-(1-methylethoxy)-2-propenal 
• 19263-02-6 2-bromo-3-hydroxypropenal 
• 747408-16-8 morpholin-3-ylideneamine 

Downstream Products

• 1062205-17-7 (3-{9-[1-(5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazin-3-ylmethyl)piperidin-4-yl]-6-morpholin-4-yl-9H-purin-2-yl}phenyl)methanol 

Relevant articles and documents

Processes For Preparing Bicyclic Oxazine Carboxaldehyde and Beta-Lactamase Inhibitors

The invention relates to processes for the preparation of the bicyclic oxazine carboxaldehyde Compound 1: The invention also relates to the use of Compound 1 in the preparation of □-lactamase inhibitors.

BICYCLIC 6-ALKYLIDENE-PENEM B-LACTAMASE INHIBITORS AND β-LACTAM ANTIBIOTIC COMBINATION: A BROAD SPECTRUM ANTIBIOTIC

The present invention provides a β-lactam antibiotic such as cefepime and a compound of formula (I), pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.

Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors

This invention relates to certain bicyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with β-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of general formula I or a pharmaceutically acceptable salt or in vivo hydrolyzable ester R5 thereof: wherein: One of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X═O or S.

PROCESS FOR PREPARING 6-ALKYLIDENE PENEM DERIVATIVES

The present invention provides a process of making compounds of Formula (I), which are useful for the treatment of bacterial infection or disease.

BICYCLIC 6-ALKYLIDENE-PENEMS AS ?-LACTAMASES INHIBITORS

The present invention provides a compound of Formula (I), pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.