Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors
This invention relates to certain bicyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with β-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of general formula I or a pharmaceutically acceptable salt or in vivo hydrolyzable ester R5 thereof: wherein: One of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X═O or S.
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Page/Page column 20
(2010/11/25)
BICYCLIC 6-ALKYLIDENE-PENEMS AS ?-LACTAMASES INHIBITORS
The present invention provides a compound of Formula (I), pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
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Page/Page column 72
(2008/06/13)
PROCESS FOR PREPARING 6-ALKYLIDENE PENEM DERIVATIVES
The present invention provides a process of making compounds of Formula (I), which are useful for the treatment of bacterial infection or disease.
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Page/Page column 100
(2010/02/07)
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