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623565-62-8

(6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL is a chemical compound that belongs to the pyrazole and oxazine classes. It is a white, crystalline solid with the molecular formula C7H8N2O2. (6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL has potential applications in medicinal chemistry and pharmaceutical research due to its structural features and potential biological activities. It may act as a building block in the synthesis of pharmaceutical compounds or may exhibit biological activity on its own. Further research and evaluation of (6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-2-yl)methanol are needed to fully understand its potential uses and properties.

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  • 623565-62-8 Structure

  • Basic information

    1. Product Name: (6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL
    2. Synonyms: (6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL
    3. CAS NO:623565-62-8
    4. Molecular Formula: C7H10N2O2
    5. Molecular Weight: 154.17
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 623565-62-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 350.0±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.43±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 13.36±0.10(Predicted)
    10. CAS DataBase Reference: (6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL(CAS DataBase Reference)
    11. NIST Chemistry Reference: (6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL(623565-62-8)
    12. EPA Substance Registry System: (6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL(623565-62-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 623565-62-8(Hazardous Substances Data)

623565-62-8 Usage

Uses

Used in Pharmaceutical Research:
(6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL is used as a building block for the synthesis of pharmaceutical compounds due to its unique structural features.
Used in Medicinal Chemistry:
(6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL is used as a compound with potential biological activities for further research and evaluation in medicinal chemistry.
Used in Drug Development:
(6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL is used as a potential candidate for drug development, as it may exhibit biological activity on its own or contribute to the development of new pharmaceutical compounds.
Used in Chemical Synthesis:
(6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL is used as a starting material or intermediate in the chemical synthesis of various compounds, particularly those with potential applications in the pharmaceutical industry.
Used in Biological Activity Studies:
(6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL is used as a subject for biological activity studies to determine its potential effects on biological systems and its suitability for use in the development of new drugs or therapies.
Used in Drug Delivery Systems:
(6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL may be used in the development of novel drug delivery systems to improve the delivery, bioavailability, and therapeutic outcomes of pharmaceutical compounds.
Used in Anticancer Applications:
While not explicitly mentioned in the provided materials, given the compound's potential biological activities and applications in medicinal chemistry, (6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL could potentially be used as an anticancer agent, similar to other compounds with similar structural features and biological activities. Further research would be required to confirm its efficacy and safety in this application.

Check Digit Verification of cas no

The CAS Registry Mumber 623565-62-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,3,5,6 and 5 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 623565-62:
(8*6)+(7*2)+(6*3)+(5*5)+(4*6)+(3*5)+(2*6)+(1*2)=158
158 % 10 = 8
So 623565-62-8 is a valid CAS Registry Number.

623565-62-8Relevant articles and documents

Polyheterocyclic substituted pyrimidines or pyridylamine derivatives Composition and medical application thereof

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Paragraph 0312-0313; 0315, (2021/09/26)

The invention discloses a polycyclic substituted pyrimidine or pyridine amine derivative, and the structure is shown in a formula (I). The invention further discloses a pharmaceutically acceptable salt of the derivative, a solvate, a stereoisomer, a prodrug, a pharmaceutical composition and and an application thereof in medicine. The compounds of the present invention have significant adenosine A. 2A Receptor and/or adenosine A2B The receptor antagonism activity is very practical.

MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS

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Paragraph 0901, (2020/08/13)

Provided are compounds represented by Formula IA: (IA), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R 1a, R 1b, L 1, L 2, L 3, X, A, B and C are as defined as set forth

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum β-lactamase inhibitors: Evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods

Venkatesan, Aranapakam M.,Agarwal, Atul,Abe, Takao,Ushirogochi, Hideki,Yamamura, Itsuka,Ado, Mihira,Tsuyoshi, Takasaki,Dos Santos, Osvaldo,Gu, Yansong,Sum, Fuk-Wah,Li, Zhong,Francisco, Gerry,Lin, Yang-I.,Petersen, Peter J.,Yang, Youjun,Kumagai, Toshio,Weiss, William J.,Shlaes, David M.,Knox, James R.,Mansour, Tarek S.

, p. 4623 - 4637 (2007/10/03)

The design and synthesis of a series of 6-methylidene penems containing [6,5]-fused bicycles (thiophene, imidazole, or pyrazle-fused system) as novel class A, B, and C β-lactamase inhibitors is described. These penems proved to be potent inhibitors of the TEM-1 (class A) and AmpC (class C) β-lactamases and less so against the class B metallo-β-lactamase CcrA. Their in vitro and in vivo activities in combination with piperacillin are discussed. On the basis of the crystallographic structures of a serine-bound reaction intermediate of 2 with SHV-1 (class A) and GC1 (class C) enzymes, compounds 14a-1 were designed and synthesized. Penems are proposed to form a seven-membered 1,4 thiazepine ring in both class A and C β-lactamases. The interaction energy calculation for the enzyme-bound intermediates favor the formation of the C7 R enantiomer over the S enantiomer of the 1,4-thiazepine in both β-lactamases, which is consistent with those obtained from the crystal structure of 2 with SHV-1 and GC1.

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