Investigations on the biotransformation of fenetylline
After oral administration of 3,7-dihydro-1,3-dimethyl-7-2[(1-methyl-2-phenylethyl)-amino-ethyl]-1H -purine-2,6-dione (fenetylline, Captagon), 7 new metabolites could be detected in urine besides 4 known substances. The metabolites were identified by gas chromatography (GC) and by comparison of the mass spectra (MS) of metabolites with those of authentic reference compounds using a combined GC/MS method.
Rucker,Neugebauer,Heiden
p. 497 - 501
(2007/10/02)
Synthesis of bronchospasmolytically effective β phenylethyl aminoalkyl xanthines
New theophylline and theobromine derivatives are synthesized from the β phenylethylaminoalkyl xanthines, whose phenyl substituent is substituted by one or two hydroxyl groups and partially also by other substituents. Different methods of synthesis are described, among them the production of the bronchospasmolytic 7 (3 [2 (3,5 dihydroxyphenyl) 2 hydroxy ethylamino] propyl) theophylline (reproterol . HCl).
Klingler
p. 4 - 14
(2007/10/05)
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