- One-Pot Synthesis of S-Acetamidomethyl-N-fluorenylmethoxycarbonyl-L-cysteine (Fmoc-Cys(Acm)-OH)
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A new strategy for the preparation of S-acetamidomethyl-N-fluorenylmethoxycarbonyl-L-cysteine is reported.Inexpensive, readily available reagents are used, and no special equipment is required.A very homogenous product is obtained after a simple crystallization at the end of the process, without purification of intermediates.
- Albericio, F.,Grandas, A.,Porta, A.,Pedroso, E.,Giralt, E.
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- Substituted pyrazole compound, preparation method, pharmaceutical composition and applications thereof
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The invention discloses a substituted pyrazole compound represented by a formula I, and a preparation method, a pharmaceutical composition and applications thereof, wherein the compound has characteristics of good stability, excellent solubility, low cytotoxicity and remarkable neuroprotective effect, can effectively prevent and treat nerve cell injury, and is an ideal medicinal compound for preventing or treating cerebral stroke, cerebral embolism, cerebral stroke sequelae, cerebral stroke dyskinesia, mitochondrial encephalomyopathy and amyotrophic lateral sclerosis of spinal cord.
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Paragraph 0409-0412; 0417
(2020/03/12)
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- Henry and Mannich reactions of polynitroalkanes in ionic liquids
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Based on Henry and Mannich reactions of polynitroalkanes for the first time implemented in ionic liquids, ecologically pure and safe methods for the synthesis of polynitro alcohols and N-2,2,2-trinitroethyl derivatives of low basic amino compounds (urea, acetamide, 4-amino-3-methylfuroxan) have been elaborated.
- Epishina, Margarita A.,Ovchinnikov, Igor V.,Kulikov, Alexander S.,Makhova, Nina N.,Tartakovsky, Vladimir A.
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scheme or table
p. 21 - 23
(2012/04/10)
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- Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole fungicidal agents
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Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole compounds which are effective for the phytopathogenic fungi are described. A method for the fungicidal use of said compounds and methods for the preparation of said compounds are presented.
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- Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole insecticidal and acaricidal agents
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Haloalkylthio, -sulfinyl and -sulfonyl arylpyrrole compounds which are effective for the control of insects and acarids are described. A method for the insecticidal and acaricidal use of said compounds and methods for the preparation of said compounds are presented.
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- N-alkanoylaminomethyl and N-aroylaminomethyl pyrrole insecticidal and acaricidal agents
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This invention relates to N-alkanoylaminomethyl and N-aroylaminomethyl pyrrole compounds. It also relates to the use of said compounds as insecticidal and acaricidal agents and to a method of protecting plants from attack by insects and acarina by application of an N-alkanoylaminomethyl or N-aroylaminomethyl pyrrole to said plants or to the locus in which they are growing.
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- Photochemistry of dipeptides in aqueous solution
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The photochemical lability of peptides is poorly understood, largely because of the lack of product data. In the present study, product analyses have been carried out following the photolyses in aqueous solution of selected glycyl dipeptides (Gly-Gly, DL-Ala-Gly, L-Val-Gly, L-Pro-Gly, L-Phe-Gly, and Gly-L-Phe), L-prolyl-L-phenylalanine, and L-phenylalanyl-L-proline. Efficient deamination and decarboxylation of aliphatic dipeptides generate thermal precursors of simple amides in a photoinduced electron-transfer process involving the peptide bond. An analogous pathway in the photodegradation of phenylalanyl peptides suffers competition from other types of reaction.
- Hill, Roger R.,Coyle, John D.,Birch, David,Dawe, Edwin,Jeffs, Graham E.,Randall, David,Stec, Iwan,Stevenson, Tessa M.
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p. 1805 - 1817
(2007/10/02)
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- Photoinduced Electron Transfer in Aliphatic Peptides
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Product analysis in the photolysis of triglycine in neutral aqueous solution suggests that the initial intramolecular electron transfer from the carboxylate to the peptide group, shown to lead to efficient (φ 0.44 +/- 0.11) photodegradation for glycylglycine, may be followed by transfer to the second peptide group.
- Birch, David,Coyle, John D.,Hill, Roger R.,Jeffs, Graham E.
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p. 293 - 295
(2007/10/02)
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- The Acid-Base Behaviour of Hexamine and its N-Acetyl Derivatives
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The protonation equilibria and decomposition reactions in aqueous hydrochloric acid of hexamine and its acylated derivatives (2), (3), and (4) have been examined by u.v. and 1H n.m.r. spectroscopy. pKa Values at 25 deg C are: hexamine 4.89, 3,7-diacetyl-1,3,5,7-tetra-azabicyclo TAT > hexamine.Reaction of hexamine with picryl acetate may involve nucleophilic catalysis via the N-acetylhexaminium cation (6).
- Cooney, Aidan P.,Crampton, Michael R.,Golding, Peter
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p. 835 - 840
(2007/10/02)
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- Kinetics and Mechanism of Reactions of Amides with Formaldehyde
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Kinetics of the reactions of substituted ureas like methylurea, phenylurea, acetamide and benzamide with formaldehyde have been studied, using a TLC method developed for the purpose.The increased reactivity of methylurea towards formaldehyde, as compared to urea, is due to the electron-releasing nature of the methyl group.The reduced reactivity of phenylurea is due to the electron-withdrawing nature of the phenyl group.The reduced reactivity observed in the case of acetamide and benzamide is also explained.
- Nair, B. Raveendran,Francis, Joseph
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p. 159 - 161
(2007/10/02)
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- Preparation of 3-chloromethyl-4-alkyl-nitrobenzene by chloromethylation
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A method for the preparation of 3-chloromethyl derivatives of 4-alkylnitrobenzenes from the corresponding amidomethyl derivatives with phosphorus oxychloride or with phosphorous oxychloride and inert solvents. This process also relates to 3-chloromethyl-4-alkylnitrobenzenes which are useful intermediates for the preparation of certain substituted 2,6-dinitroaniline pre-emergence herbicides.
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- Process for the preparation of somatostatin
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The present invention relates to a new process for the stepwise preparation of somatostatin enabling a product of high purity to be obtained, with high yields, from cysteine in 14 position whose acid function is protected by the phenylazobenzylsulfonylethyloxy group and thiol function is protected by the acetamidomethyl group, all the peptide coupling reactions being effected in liquid phase in the dimethylformamide, the intermediate peptides being precipitated by addition of a second solvent and purified in solid phase by washing with the aid of suitable solvents dissolving the impurities.
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- Extremely low viscosity adducts of lactams with alcohols
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Adducts useful as solvents are prepared from lactams and an aliphatic, cycloaliphatic or araliphatic alcohol or thioalcohol. Solutions of the adducts in the lactam, alcohol or thioalcohol are also disclosed as well as a process for preparing the adducts and solutions thereof.
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