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N1-(3-MORPHOLINOPROPYL)BENZENE-1,2-DIAMINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 62553-49-5 Structure
  • Basic information

    1. Product Name: N1-(3-MORPHOLINOPROPYL)BENZENE-1,2-DIAMINE
    2. Synonyms: N1-(3-MORPHOLINOPROPYL)BENZENE-1,2-DIAMINE
    3. CAS NO:62553-49-5
    4. Molecular Formula: C13H21N3O
    5. Molecular Weight: 235.33
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 62553-49-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N1-(3-MORPHOLINOPROPYL)BENZENE-1,2-DIAMINE(CAS DataBase Reference)
    10. NIST Chemistry Reference: N1-(3-MORPHOLINOPROPYL)BENZENE-1,2-DIAMINE(62553-49-5)
    11. EPA Substance Registry System: N1-(3-MORPHOLINOPROPYL)BENZENE-1,2-DIAMINE(62553-49-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 62553-49-5(Hazardous Substances Data)

62553-49-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 62553-49-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,5,5 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 62553-49:
(7*6)+(6*2)+(5*5)+(4*5)+(3*3)+(2*4)+(1*9)=125
125 % 10 = 5
So 62553-49-5 is a valid CAS Registry Number.

62553-49-5Relevant articles and documents

Benzimidazole Derivatives as Novel Zika Virus Inhibitors

Anh, Le Duc,De, Tran Quang,Duc Thanh, Danh La,Dupont-Rouzeyrol, Myrielle,Grailhe, Regis,Hue, Bui Thi Buu,Jo, Eunji,Nguyen, Phuong Hong,Son, Nguyen Hoang,Thoa, Than Thi,Van Hieu, Mai,Van Tuan, Nguyen,Windisch, Marc P.

, p. 1453 - 1463 (2020/05/25)

We have synthesized 50 benzimidazole (BMZ) derivatives with 1,2-phenylenediamines and aromatic aldehydes under mild oxidation conditions by using inexpensive, nontoxic inorganic salt sodium metabisulfite in a one-pot condensation reaction and screened their ability to interfere with Zika virus (ZIKV) infection utilizing a cell-based phenotypic assay. Seven BMZs inhibited an African ZIKV strain with a selectivity index (SI=CC50/EC50) of 9–37. Structure-activity relationship analysis demonstrated that substitution at the C-2, N-1, and C-5 positions of the BMZ ring were important for anti-ZIKV activity. The hybrid structure of BMZ and naphthalene rings was a structural feature responsible for the high anti-ZIKV activity. Importantly, BMZs inhibited ZIKV in human neural stem cells, a physiologically relevant system considering the severe congenital anomalies, like microcephaly, caused by ZIKV infection. Compound 39 displayed the highest antiviral efficacy against the African ZIKV strain in Huh-7 (SI>37) and neural stem cells (SI=12). Compound 35 possessed the highest activity in Vero cells (SI=115). Together, our data indicate that BMZs derivatives have to be considered for the development of ZIKV therapeutic interventions.

Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[ a[phenazin derivatives as dual topoisomerase I/II inhibitors

Yao, Bing-Lei,Mai, Yan-Wen,Chen, Shuo-Bin,Xie, Hua-Ting,Yao, Pei-Fen,Ou, Tian-Miao,Tan, Jia-Heng,Wang, Hong-Gen,Li, Ding,Huang, Shi-Liang,Gu, Lian-Quan,Huang, Zhi-Shu

, p. 540 - 553 (2015/01/30)

A novel series of benzo[a]phenazin derivatives bearing alkylamino side chains were designed, synthesized and evaluated for their topoisomerases inhibitory activity as well as cytotoxicity against four human cancer cell lines (HL-60, K-562, HeLa, and A549)

Parallel synthesis of a series of potentially brain penetrant aminoalkyl benzoimidazoles

Micco, Iolanda,Nencini, Arianna,Quinn, Joanna,Bothmann, Hendrick,Ghiron, Chiara,Padova, Alessandro,Papini, Silvia

, p. 2313 - 2328 (2008/09/21)

Alpha7 agonists were identified via GOLD (CCDC) docking in the putative agonist binding site of an alpha7 homology model and a series of aminoalkyl benzoimidazoles was synthesised to obtain potentially brain penetrant drugs. The array was prepared startin

Benzimidazole derivative, hair growth promoter and external composition for skin using the same

-

, (2008/06/13)

A benzimidazole derivative or a salt thereof expressed by the following Formula (I): wherein one of A and B is a hydrocarbon group of C10-30expressed by R1and the other is —(CH2)n—NR2R3; R

Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines

-

, (2008/06/13)

1-[3-(Dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)propyl]imidazo[4,5-b]pyridines and salts thereof with pharmaceutically acceptable acids, a novel class of compounds useful in the treatment of inflammatory conditions. Alternate methods of preparation are provided and the primary synthetic route is described in detail.

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