- Nonenzymatic Dynamic Kinetic Resolution of in situ Generated Hemithioacetals: Access to 1,3-Disubstituted Phthalans
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The first nonenzymatic DKR reaction of hemithioacetals is developed. Hemithioacetals were formed in situ via thiol addition and subsequently underwent an intramolecular oxa-Michael reaction. The scope of the reaction was quite broad ranging from aliphatic to aromatic substituents and 1,3-disubstituted-1,3-dihyroisobenzofuran products were obtained in good yields with moderate diastereoselectivities and high enantioselectivities. (Figure presented.).
- Nath, Utpal,Chowdhury, Deepan,Pan, Subhas Chandra
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p. 1628 - 1633
(2018/03/21)
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- Base-Induced Cyclization of Propargyl Alkenylsulfones: A High-Yielding Synthesis of 4,5-Disubstituted 2H-Thiopyran 1,1-Dioxides
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A convenient synthesis of 4,5-disubstituted 2H-thiopyran 1,1-dioxides is reported through a base induced process starting from eneyne sulfones. Except for strongly electron-withdrawing groups, the reaction tolerated a wide variety of substituents in the t
- Hatial, Ishita,Das, Joyee,Ghosh, Ananta K.,Basak, Amit
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p. 6017 - 6024
(2015/09/22)
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- Ga(OTf)3-catalyzed direct substitution of alcohols with sulfur nucleophiles
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It is reported that Ga(OTf)3 catalyzes the direct displacement of alcohols with sulfur nucleophiles. The products are versatile intermediates that can be utilized in carbon - carbon, carbon - sulfur bond formation or used in modified Julia olef
- Han, Xinping,Wu, Jimmy
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supporting information; scheme or table
p. 5780 - 5782
(2011/03/18)
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- Synthesis of thiols via palladium catalyzed methanolysis of thioacetates with borohydride exchange resin
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Various thiols are prepared quantitatively from the corresponding thioacetates via Pd catalyzed methanolysis with borohydride exchange resin under a mild and neutral conditions. One-pot synthesis of thiols from alkyl halides through the formation of alkyl thioacetates using thioacetate exchange resin followed by methanolysis is also described.
- Choi,Yoon
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p. 2655 - 2663
(2007/10/02)
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- Direct Conversion of Alcohols into Thiols
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A simple one-pot reaction between alcohols and 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (Lawesson's reagent, LR) affords the corresponding thiols, accompanied by dehydration products, alkenes.Treatment of acyclic 1,4-diols with LR gives the 1,3-dienes. o-(Dihydroxymethyl)benzene derivatives yield the 1,3-dihydrobenzothiophenes when treated with LR.
- Nishio, Takehiko
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p. 1113 - 1118
(2007/10/02)
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- A Novel Transformation of Alcohols to Thiols
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Treatment of alcohols with 2,4-bis(p-methoxyphenyl)-1,3-dithiaphosphetane-2,4-disulphide (Lawesson reagent) gave the corresponding thiols.
- Nishio, Takehiko
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p. 205 - 206
(2007/10/02)
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- A NEW, HIGHLY EFFICIENT METHOD FOR THE CONVERSION OF ALCOHOLS TO THIOLESTERS AND THIOLS
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Various alcohols were converted to their corresponing thiolacetates by treatment with triphenylphosphine and diisopropyl azodicarboxylate in the presence of thiolacetic acid.The overall conversion was both highly efficient (89-99percent yields) and stereoselective (99.5percent inversion).
- Volante, R. P.
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p. 3119 - 3122
(2007/10/02)
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